Early detection of disease using surface enhance Raman scattering (SERS)-dynamic gold nanoparticle to detect inflammatory response in cells
Project/Area Number |
24700481
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Osaka University |
Principal Investigator |
PISSUWAN Dakrong 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (40622147)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 金ナノ粒子 / SERS / 炎症反応 / ICAM-1 / サイトカイン |
Research Abstract |
The investigation of the use of surface enhanced Raman scattering (SERS) gold nanoparticles for rapid monitoring of inflammatory responses at the early stage of diseases. Gold nanorods (GNRs) combined with Raman probes (4-mercaptobenzoic acid) are conjugated with intercellular adhesion molecule-1 antibody (anti-ICAM-1). The prepared particles could be used as a SERS probe to detect the expression of ICAM-1 in macrophages treated lipopolysaccharide for 1 h which is faster than using ELISA or fluorescent labeling techniques.
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Report
(3 results)
Research Products
(15 results)
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[Presentation] Transdermal insulin delivery enhanced by phptothermal effect of gold nanorods2012
Author(s)
Pissuwan, D., Nose, K., Mori, T., Katayama, Y., Niidome, T.
Organizer
Controlled Release Society (CRS) Meeting
Place of Presentation
Centre des congress de Quebec, Quebec City, Canada
Related Report
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