The development of reliable biomarker measurement systems considered for human cancer tissue heterogeneity.
| Project/Area Number |
24700501
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
Nagai Takeshi 東京医科大学, 医学部, 兼任助教 (60384989)
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| Research Collaborator |
Oshiro Hisashi 自治医科大学, 医学部, 教授 (60381513)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 仮想組織マイクロアレイ / 病理診断学 / Ki-67 index / Apoptosis index / digital microscopy / Bland-Altman plot 分析 / systematic bias / ヒト癌組織の不均一性 / 膀胱癌 / Ki-67 / アポトーシス / ヴァーチャル組織マイクロアレイ / 腫瘍病理学 / バーチャル組織マイクロアレイ / 人間医工学 / 医用システム / 検査・診断法 / 検査･診断法 |
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| Outline of Final Research Achievements |
Digital microscopy-assisted, computerized image analysis enabled us to easily quantify histopathological heterogeneity in human cancer tissues, leading to a high level of quantitative and reproducible capability for biomarker measurement results. Our study suggests that the measurement results for certain biomarkers obtained from tissue microarray-based samples can be susceptible to systematic bias, and the lack of correlation between biomarkers cannot be avoided as it is in whole mount tissue preparations. Virtual tissue microarray in combination with Bland-Altman plot analysis can be useful for identifying a systematic bias, and this will help to establish a better sampling strategy for reliable biomarker measurements considered for human cancer tissue heterogeneity.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP2013
Author(s)
Kusama K, Yoshie M, Tamura K, Kodaka Y, Hirata A, Sakurai T, Bai H, Imakawa K, Nishi H, Isaka K, Nagai T, Nagao T, Tachikawa E.
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Journal Title
Placenta
Volume: 34
Pages: 212-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma2012
Author(s)
Usui Y, Wakabayashi Y, Okunuki Y, Kimura K, Tajima K, Matsuda R, Ueda S, Ma J, Nagai T, Mori H, Kezuka T, Nagao T, Goto H.
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 53
Pages: 5395-402
DOI
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice2012
Author(s)
Nagao T, Sato E, Inoue R, Oshiro H, Takahashi RH, Nagai T, Yoshida M, Suzuki F, Obikane H, Yamashina M, Matsubayashi J.
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Journal Title
ACTA HISTOCHEMICA ET CYTOCHEMICA
Volume: 45
Issue: 5
Pages: 269-282
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 子宮頸部擦過塗抹標本上に出現した悪性リンパ腫の3例2015
Author(s)
稲垣 敦史, 永井 毅, 三宅 真司, 渡部 顕章, 山口 真由実, 川内 ゆうか, 石原 里佳子, 大城 久, 松林 純, 佐川 泰一, 中村 直哉, 長尾 俊孝
Organizer
第54回日本臨床細胞学会秋季大会
Place of Presentation
名古屋国際会議場（愛知県名古屋市）
Year and Date
2015-11-21
Related Report
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[Presentation] 炎症性筋線維芽細胞腫様の形態を示した未分化肉腫の1例2015
Author(s)
片場 寛明, 前田 純一, 吉田 浩一, 垣花 昌俊, 梶原 直央, 筒井 英光, 大平 達夫, 永井 毅, 松林 純, 長尾 俊孝, 池田 徳彦
Organizer
第54回日本臨床細胞学会秋季大会
Place of Presentation
名古屋国際会議場（愛知県名古屋市）
Year and Date
2015-11-21
Related Report
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[Presentation] 分葉状頸管腺過形成が共存した子宮頸部胃型腺癌の一例2013
Author(s)
島田 ゆうか, 永井 毅, 小池 悦子, 三宅 真司, 片桐 仁子, 礒本 愛子, 大塚 清花, 長谷部 俊二, 松林 純, 大城 久, 高橋 礼典, 佐川 泰一, 長尾 俊孝
Organizer
日本臨床細胞学会
Place of Presentation
大阪
Related Report
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