Development of ultrasound-induced phonophoresis to promote scar healing
| Project/Area Number |
24700530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
TORII Kazuhiro
TABUCHI Hiroto
SAKA Ayumi
ARAKI Kyoko
KOGA Yuka
OCHI Akane
UEMURA Mikiko
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 超音波 / 短鎖脂肪酸 / 線維化 / 線維芽細胞 / 瘢痕 / 超音波療法 / 脂肪酸 / ソノポレーション / フォノフォレーシス |
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| Outline of Final Research Achievements |
We elucidated the ultrasound parameters to promote the antifibrogenic and anti-inflammatory effects by short chain fatty acids. Butyrate is a fatty acid having the most potent physiological action among short chain fatty acids. We found the antifibrogenic effects of butyrate in human dermal fibroblasts, keloid fibroblasts and pterygium fibroblasts, and facilitatory effects of low-intensity ultrasound (0.1-0.5 W/cm2) for the antifibrogenic and anti-inflammatory effects by butyrate. In addition, we found the promotional effects of low-intensity ultrasound on histone acetylation by a low-concentration of butyrate.
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Report
(5 results)
Research Products
(20 results)
