Biochemical analysis of mechanical stimulation on osteoarthritis
| Project/Area Number |
24700531
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHTSUKI Takashi 岡山大学, 医学部, 客員研究員 (10534802)
HIROHATA Satoshi 岡山大学, 国際センター, 准教授 (90332791)
|
|---|
| Research Collaborator |
KAWAMURA Kenji 吉備国際大学, 保健医療福祉学部, 教授 (40278974)
SHINAOKA Akira 岡山大学, 医学部, 客員研究員
SAKAI Takafumi 吉備国際大学, 保健福祉学部, 客員研究員
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | 変形性膝関節症 / リハビリテーション / ヒアルロン酸 / 運動療法 / CTXII / 運動機能 |
|---|
| Research Abstract |
The purpose of this study is to analyze the effect of intra-articular injection of hyaluronan(HA) with or without mechanical stimulation (MS) using shaking board (OG giken) on osteoarthritis patients. Therefore we used physiological and biochemical methods. In our study, patients were divided into four groups, 1(normal therapy (NT)), 2(NT + HA treatment), 3(NT + MS) and 4(NT + HA treatment + MS). Uterine collagen C telopeptide (U-CTX) was used as cartilage degradation marker. Patient group 4 significantly decreased U-CTX concentration in compared with other groups. Furthermore, U-CTX levels significantly decreased in patients of slight symptom in compared severe symtom patients.
In conclusion, our results show that HA treatment with mechanical stimulation in early OA stage attenuate articular degradation in OA patients.
|
Report
(3 results)
Research Products
(6 results)
