Experimental study for establishment a new therapeutic approach for immobilized-induced joint contracture
| Project/Area Number |
24700539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAKAMOTO Junya 長崎大学, 医歯薬学総合研究科(保健学科), 准教授 (20584080)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 不動 / 拘縮 / 骨格筋 / 線維化 / 磁気刺激 / 筋性拘縮 / 筋収縮運動 / 低酸素 |
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| Outline of Final Research Achievements |
This study aimed to establish a new therapeutic approach for patients being treated with immobilization and orthosis through investigation that the effects of muscle contraction induced by lumbar magnetic stimulation and neuromuscular electric stimulation on immobilization-induced limited ROM and skeletal muscle fibrosis in rat soleus muscle.
As results, isometric twitch contraction via lumbar magnetic stimulation and neuromuscular electric stimulation decreased skeletal fibrosis fibrosis and reduced the progression of ROM loss. By contrast, the effect of tetanic contraction for fibrosis and progression of ROM loss was insufficient. We believe that isometric twitch contraction via lumbar magnetic stimulation and neuromuscular electric stimulation holds potential as a new therapeutic approach for immobilization-induced loss of ROM.
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Report
(4 results)
Research Products
(16 results)
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[Presentation] The up-regulation of IL-1b/TGF-b and hypoxia induced in immobilization are related to the molecular mechanisms underlying muscle contracture.2013
Author(s)
Honda Y, Kondo Y, Sasabe R, Sekino Y, Morimoto Y, Kataoka H, Sakamoto J, Nakano J, Yoshimura T, Okita M
Organizer
World Congress of Neurology
Place of Presentation
Vienna, Austria
Related Report
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