Effect of heat stress on contractile properties of skeletal muscle from adjuvant-induced arthritis rat
| Project/Area Number |
24700541
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
YAMADA Takashi 札幌医科大学, 保健医療学部, 講師 (50583176)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 関節リウマチ / 筋力低下 / 炎症性サイトカイン / パーオキシナイトライト / 熱刺激 / 熱ショックタンパク質 / 筋弱化 / 固有張力 / 酸化ストレス / ミオシンATPase / SERCA |
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| Research Abstract |
Patients with rheumatoid arthritis (RA) have significant muscle weakness, which has a major impact on disability in conjugation with disease activity. In the present study, we investigated the underlying mechanisms of contractile dysfunctions in skeletal muscle from adjuvant-induced arthritis (AIA) rats, which is a widely used animal model for RA. The results show intrinsic contractile dysfunction in extensor digitorum longus (EDL) muscles of AIA rats, which can be explained by the oxidative stress due to TNF-induced peroxynitrite overproduction. Moreover, take these findings and the antioxidative role of heat shock protein (Hsp) 72 into account, we investigated the effects of heat stress on the contractile properties and redox states of AIA EDL muscles. Our results show that heat stress markedly increases Hsp72 expression, but fails to ameliorate contractile dysfunctions and redox modifications in AIA EDL muscles.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mtDNA mutator mice2012
Author(s)
Yamada, T., Ivarsson, N., Herrnandez, A., Fahlstrom, A., Cheng, AJ., Bruton, JD., Ulfhake, B., Westerblad, H
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Journal Title
J. Physiol
Volume: 590
Issue: 23
Pages: 6187-6197
DOI
Related Report
Peer Reviewed
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[Presentation] 関節リウマチに伴う筋力低下における窒素化ストレスの役割2012
Author(s)
山田崇史, 倉谷麻衣, 神崎圭太, 三島隆章, 松永智, 和田正信
Organizer
Gordon Research Conferences (Muscle : Excitation/ Contraction Coupling)
Place of Presentation
Les Diablerets, Switzerland
Related Report
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[Presentation] Cardiac Ca2+ and free radical disturbances in mice with arthritis2012
Author(s)
Lanner, JT., Andersson, D., Yamada, T., Zong, M., Lundberg, IE., sterblad, H.
Organizer
Gordon Research Conferences (Muscle : Excitation/Contraction Coupling)
Place of Presentation
Les Diablerets, Switzerland
Related Report
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[Presentation] Involvement of crosstalk between nitrosative stress and altered Ca2+ handling properties in arthritis-induced skeletal muscle dysfunction2012
Author(s)
Yamada, T., Ivarsson, N., Grundtman, C., Zhang, SJ., Erlandsson-Harris, H., Lundberg, IE., Bruton, JD., Westerblad, H.
Organizer
Gordon Research Conferences (Muscle : Excitation/Contraction Coupling)
Place of Presentation
Les Diablerets, Switzerland
Related Report
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