| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Alterations in the number and size of motoneurons were studied in the medial gastrocnemius (MG) motor nucleus of diabetic rats and age-matched controls. MG motoneurons were retrogradely labeled and the number and size of cell bodies were examined. Additionally, we investigate the prevention effect of 20 weeks of exercise training on motoneuronal loss in diabetic rats.
Significantly fewer labeled MG motoneurons were found in diabetic rats as compared with control animals. The size distribution of MG nucleus was bimodal; cells with larger size were presumed to be alpha-motoneurons and those with smaller were presumed to be gamma. Compared to control animals, the number of smaller MG motoneurons was reduced in diabetic animals but exercise training prevent decrease the number of MG motoneurons.We conclude that there is a significant decrease occurred predominantly among the smaller gamma- motoneurons and there is a possibility that exercise training prevent these motoneuronal loss.
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