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Influence of the difference in muscle regeneration between young and adult rat on development of musculoskeletal chronic pain.

Research Project

Project/Area Number 24700565
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTokoha University (2013-2014)
Hamamatsu University (2012)

Principal Investigator

SAKURAI Hiroki  常葉大学, 保健医療学部, 准教授 (60454419)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords慢性痛 / 運動器 / 生後発達 / 関連物質 / 生体物質
Outline of Final Research Achievements

Clinically, it is known that the incidence of chronic pain is much lower in children than in adults. The low-incidence may disclose some important factors to develop chronic pain in the adulthood. In this study, we treated to the young rat in the musculoskeletal chronic pain model procedure we have developed. The treatment to adult rats produced long-persisting pain behaviors, on the contrary, the treatment to young rats did not develop chronic pain behaviors. In damaged skeletal muscle, time course of recovery observed almost same between young and adult rat. Though, the expression level of TNFα and myogenin were different both acute and chronic period of treatment. These results suggest that muscle developmental factor and immune system in skeletal muscle coordinate the pathogenesis of musculoskeletal chronic pain.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization.2014

    • Author(s)
      Mika Ohmichi
    • Journal Title

      Molecular Pain

      Volume: 24 Pages: 6-6

    • DOI

      10.1186/1744-8069-10-6

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treadmill running and static stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats.2013

    • Author(s)
      Morimoto A
    • Journal Title

      Neurosci Lett

      Volume: 534 Pages: 295-300

    • DOI

      10.1016/j.neulet.2012.11.009

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ギプス固定後慢性痛モデルの広範囲機械痛覚過敏の発症に関わる阻血再潅流障害とその長期維持に関わる脊髄アストロサイトの活性化2014

    • Author(s)
      大道裕介, 大道美香, 李玉強, 櫻井博紀, 大石仁, 中野隆, 浅本憲, 佐藤純
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] トレッドミル運動およびスタティックストレッチングはラット後肢ギプス固定後にみられる痛覚過敏、関節可動域制限および筋萎縮を改善した2014

    • Author(s)
      森本温子, Winaga Handriadi,  櫻井博紀, 大道裕介, 大道美香, 牛田享宏, 佐藤純
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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