Exercise training facilitates recovery from muscle atrophy by stimulating proliferation of myogenic satellite cells

• Project/Area Number: 24700566
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya Gakuin University
• Principal Investigator: ITOH Yuta 名古屋学院大学, リハビリテーション学部, 助教 (30454383)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: リハビリテーション科学 / 運動療法学 / 動物 / 細胞生物学 / 骨・筋肉

Outline of Final Research Achievements

To know the cellular mechanism of exercise-dependent facilitating recovery of atrophied muscle, I examined the effects of exercise on the number of nuclei of individual myofibers in atrophied and normal muscles. Results, the exercise promoted recovery of atrophied myofiber CSA, and the number of newly generated myonuclei increses. And proliferation, differentiation and fusion of myogenic satellite cells were observed, suggesting that the activation of myogenic satellite cells induced by exercise effectively facilitate the recovery of size of myofibers from the muscle atrophy.

Research Products

• [Journal Article] Stand-up exercise training facilitates muscle recovery from disuse atrophy by stimulating myogenic satellite cell proliferation in mice (2014)
  • Author(s): Yuta Itoh, Kimihide Hayakawa, Tomohiro Mori, Nobuhide Agata, Masumi Inoue-Miyazu, Taro Murakami, Masahiro Sokabe, Keisuke Kawakami
  • Journal Title: Physiological Reports Volume: 2（11） Issue: 11 Pages: 1-10
  • DOI: 10.14814/phy2.12185
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The effective intensity of exercise load for facilitating recovery from muscle atrophy in mice (2015)
  • Author(s): Yuta Itoh, Nobuhide Agata, Nahoko Kimura, Masumi Inoue-Miyazu, Takayuki Hirano, Kimihide Hayakawa, Taro Murakami, Keisuke Kawakami
  • Organizer: WCPT2015
  • Place of Presentation: Suntec Singapore International Convention and Exhibition Centre （Suntec ）
  • Year and Date: 2015-05-01 – 2015-05-04
• [Presentation] 筋損傷を引き起こす強度の運動は筋萎縮からの回復促進効果を下げる (2014)
  • Author(s): 伊東佑太、縣信秀、木村菜穂子、宮津真寿美、平野孝行、河上敬介
  • Organizer: JPTA第1回日本基礎理学療法学会学術集会・JPTF日本基礎理学療法学会第4回学術大会 合同学会
  • Place of Presentation: 名古屋学院大学（愛知）
  • Year and Date: 2014-11-15 – 2014-11-16
• [Presentation] Isometric Contraction by Electrical Stimulation Facilitats Recovery from Muscle Atrophy (2013)
  • Author(s): Yuta Itoh, Kiyoshi Yoshioka, Nobuhide, Masumi Inoue-, Keisuke
  • Organizer: WCPT-AWP & ACPT Congress 2013
  • Place of Presentation: Nan Shan Education & Training Center (ETC), Taichung, Taiwan
• [Presentation] マウスヒラメ筋の筋萎縮からの回復促進効果と筋収縮負荷量との関係 (2013)
  • Author(s): 伊東佑太、吉岡潔志、森友洋、縣信秀、木村菜穂子、宮津真寿美、河上敬介
  • Organizer: 第3回日本基礎理学療法学会学術大会
  • Place of Presentation: 名古屋大学医学部保健学科
• [Presentation] 筋力増強運動による組織学的な回復促進効果は筋力の回復を伴うか？ (2013)
  • Author(s): 村田奈緒子、伊東佑太、吉岡潔志、河上敬介
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 筋力増強運動による萎縮筋の筋線維核数増加の時期や量 (2012)
  • Author(s): 伊東佑太、藤田佳菜子、縣信秀、宮津真寿美、平野孝行、河上敬介
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸国際展示場
• [Remarks] 名古屋学院大学 研究等業績一覧
  • URL: http://www.ngu-kenkyu-db.jp/
• [Remarks] 名古屋学院大学 研究等業績一覧
  • URL: http://www.ngu-kenkyu-db.jp/
• [Remarks] 名古屋学院大学 研究等業績一覧
  • URL: http://www.maruron-ac.net/ngu-u/public/