| Project/Area Number |
24700567
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nihon Fukushi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 筋萎縮 / ストレッチ / 熱刺激 / 骨格筋 / メカニカルストレス / heat shock protein / FOXO / NF-κB |
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| Research Abstract |
The present study aimed to investigate the effects of combination of stretching and heat stimulation on the progression and recovery of skeletal muscle atrophy in vitro and vivo. The results demonstrate that heat stimulation can prevent the progression of skeletal muscle atrophy, and this effect is linked to the suppression of protein catabolic signaling activities. The study also suggests that stretching improves recovery of skeletal muscle after disuse atrophy, possibly through the activation of anabolic signaling pathways. Hence, the combination of the heat stimulation and stretching may be effective in both inhibiting protein degradation and stimulating protein synthesis in skeletal muscle atrophy for patients with limited mobility.
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