An experimental study on the effect of therapy with both skeletal muscle hyperthermia and electrical stimulation for diabetes mellitus
| Project/Area Number |
24700568
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nihon Fukushi University |
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Principal Investigator |
IWATA Masahiro 日本福祉大学, 健康科学部, 准教授 (60448264)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | インスリン抵抗性 / 骨格筋 / 温熱刺激 / 電気刺激 / インスリン感受性 / heat shock protein / glucose transporter / 糖尿病 / glucose transporter 4 |
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| Research Abstract |
The purpose of this study was to analyze the effect of therapy with both heat stress and electrical stimulation on amelioration of insulin resistance. In vitro experiments by using TNF-alpha-treated insulin-resistant C2C12 myotubes, both heat stress and electrical stimulation increased insulin-stimulated glucose uptake, but the effects were not additive. In vivo experiments by using high-fat diet-fed insulin-resistant rats, the daily application of electrical stimulation improved insulin action and increased HSP72 and GLUT4 expression in the rectus femoris muscle. The present results suggest that the daily application of electrical stimulation can ameliorate insulin resistance, and this mechanism is related to increased expression of HSP72 and/or GLUT4 in myocytes.
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Report
(3 results)
Research Products
(29 results)
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[Presentation] Mechanical stretching increases glucose transport into skeletal myocytes in culture by mechanism other than via adenosine triphosphate2013
Author(s)
Iwata M, Tsuchida W, Yuminamochi R, Banno Y, Inoue T, Fujiwara M, Hayashi K, Matsuo S, Asai Y, Suzuki S
Organizer
34th Annual Meeting International Gravitational Physiology
Place of Presentation
Honokuni Toyohashi Art Theater PLAT (Toyohashi, Japan)
Year and Date
2013-06-24
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[Presentation] 14th World Congress of Pain (IASP)2012
Author(s)
Hayashi K, Suzuki S, Inukai N, Inoue T, Imoto S, Banno Y, Iwata M, Fujiwara M
Organizer
14th World Congress of Pain (IASP)
Place of Presentation
Milano Convention Centre (Milan, Italy)
Year and Date
2012-08-31
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[Book] ストレッチングの科学2013
Author(s)
鈴木重行, 岩田全広, 坂野裕洋, 井上貴行, 松尾真吾, 波多野元貴
Total Pages
230
Publisher
三輪書店
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