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The molecular mechanism of neural network reorganization after stroke

Research Project

Project/Area Number 24700572
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKawasaki Medical School

Principal Investigator

OKABE Naohiko  川崎医科大学, 医学部, 助教 (30614276)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywordsリハビリテーション / 脳梗塞
Outline of Final Research Achievements

It has been well known that the neural network is reorganized after cerebral infarct to compensate the lost function. However, the mechanism underlying the neural network reorganization is not known. In previous study, we found that the rehabilitation therapy causes the secondary motor cortex forelimb area expansion after cerebral infarct in primary motor cortex forelimb area in rat. Anatomical analysis revealed that the rehabilitation therapy enhanced axon growth in spinal cord, suggesting rehabilitation therapy induces motor map reorganization by promoting axon remodeling in spinal cord.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Remarks (3 results)

  • [Journal Article] Neuroprotection of granulocyte colony-stimulating factor during the acute phase of transient forebrain ischemia in gerbils.2014

    • Author(s)
      Lu F, Nakamura T, Toyoshima T, Liu Y, Shinomiya A, Hirooka K, Okabe N, Miyamoto O, Tamiya T, Keep RF, Itano T
    • Journal Title

      Brain Res

      Volume: 1548 Pages: 49-55

    • DOI

      10.1016/j.brainres.2013.12.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke2013

    • Author(s)
      Okabe N, Nakamura E, Himi N, Narita K, Tsukamoto I, Maruyama T, Sakakibara N, Nakamura T, Itano T, Miyamoto O
    • Journal Title

      Brain Research

      Volume: 1506 Pages: 115-131

    • DOI

      10.1016/j.brainres.2013.02.009

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Spatiotemporal analysis of motor map reorganization after stroke2015

    • Author(s)
      岡部直彦、城本高志、陸豊、丸山恵美、氷見直之、岩知道信久、成田和彦、宮本修
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      兵庫県・神戸市・神戸国際会議場
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳梗塞後の運動野再構成に対するリハビリテーションの時空間的影響の検討2014

    • Author(s)
      岡部直彦、城本高志、陸豊、丸山恵美、氷見直之、岩知道信久、成田和彦、宮本修
    • Organizer
      第26回日本脳循環代謝学会総会
    • Place of Presentation
      岡山県・岡山市・岡山コンベンションセンター
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳梗塞後の運動野再構成に対するリハビリテーションの時間空間的影響の検討2014

    • Author(s)
      岡部直彦、城本高志、陸豊、丸山恵美、氷見直之、岩知道信久、成田和彦、宮本修
    • Organizer
      中四国生理学会
    • Place of Presentation
      香川県・高松市・情報通信交流館 e-とぴあ・かがわ
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Spatiotemporal effects of rehabilitation therapy on motor map reorganization after stroke2014

    • Author(s)
      岡部直彦、城本高志、陸豊、丸山恵美、氷見直之、岩知道信久、成田和彦、宮本修
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke2013

    • Author(s)
      Okabe N, Nakamura E, Himi N, Narita K, Tsukamoto I, Maruyama T, Sakakibara N, Nakamura T, Itano T, Miyamoto O.
    • Organizer
      The 90th annual meeting of the physiological society of Japan
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Research-status Report
  • [Remarks] 川崎医科大学 生理学2

    • URL

      http://www.kawasaki-m.ac.jp/physiology

    • Related Report
      2014 Annual Research Report
  • [Remarks] 川崎医科大学 生理学2

    • URL

      http://www.kawasaki-m.ac.jp/physiology/

    • Related Report
      2013 Research-status Report
  • [Remarks] 川崎医科大学 生理学2

    • URL

      http://www.kawasaki-m.ac.jp/physiology/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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