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Basic research toward locomotion assistance with bi-directional brain-machine interfaces

Research Project

Project/Area Number 24700587
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionThe University of Tokyo

Principal Investigator

FUKAYAMA Osamu  東京大学, 情報理工学(系)研究科, 助教 (30508205)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsブレイン-マシンインタフェース / 小動物移動ロボット / 大脳可塑性 / 微小電気刺激 / ブレイン-マシンインタフェース
Research Abstract

Brain-machine interfaces (BMI) have enabled to record intracortical activity of neurons to estimate motor commands. However, observable neurons are strictly limited to those near implanted electrodes, which has been an obstacle to acquire sufficient patterns for motor complexity. We have initiated a challenge to apply micro-current stimuli in the motor cortex of a rat to induce plastic changes of those neurons so that they are more correlated with the locomotion.
For the purpose, RatCar system that we have developed as an integrated BMI holding a rat inside a vehicle has been improved to include an on-board recorder, a stimulator, a neural processor, and batteries for stable wireless operation more than 30 minutes. In addition, cortical stimuli were applied triggered by a rat stepping forward. It has induced changes of neural activity patterns during the locomotion, although the direct correlation with locomotion velocity did not necessarily increased.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2014 2013 2012 Other

All Journal Article (2 results) Presentation (32 results) Remarks (2 results)

  • [Journal Article] 考える-ブレイン/マシンインタフェースの応用事例2012

    • Author(s)
      満渕邦彦, 深山理
    • Journal Title

      電気学会誌

      Volume: Vol. 132, No. 7 Pages: 425-425

    • NAID

      10030777648

    • Related Report
      2013 Final Research Report
  • [Journal Article] 考える - ブレイン/マシンインタフェースの応用事例2012

    • Author(s)
      満渕 邦彦,深山 理
    • Journal Title

      電気学会誌

      Volume: 132(7) Pages: 425-428

    • NAID

      10030777648

    • Related Report
      2012 Research-status Report
  • [Presentation] 中枢微小電気刺激によるラット大脳皮質の局所変化誘発に関する検討2014

    • Author(s)
      中西良介、横田将尭、深山理、鈴木隆文、満渕邦彦
    • Organizer
      電気学会 医用・生体工学研究会
    • Place of Presentation
      東京工業大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 末梢神経からの計測信号に混入する筋電除去のための電極構造および信号処理に関する検討2014

    • Author(s)
      高野光浩、深山理、満渕邦彦
    • Organizer
      電気学会 医用・生体工学研究会
    • Place of Presentation
      東京工業大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 車体型 BMI ラットカーの持続的駆動に向けた皮質刺激による神経活動制御の試み2014

    • Author(s)
      深山理、横田将尭、中西良介、満渕邦彦
    • Organizer
      第 53 回 日本生体医工学会大会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Automatic Locomotion-triggered Intracortical stimu- lating system for a rat2013

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      Society for Neuro- science Annual Meeting 2013
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Bi-directional interfacing on motor nervous system with RatCar2013

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2013
    • Place of Presentation
      慶応大学(神奈川県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 末梢感覚入力に同期した慢性的大脳皮質刺激装置によるラット脳機能の局所変化誘発に関する検討2013

    • Author(s)
      中西良介, 横田将尭, 深山理, ほか
    • Organizer
      平成25年電気学会電子・情報・システム部門大会
    • Place of Presentation
      北見工業大学(北海道)
    • Related Report
      2013 Final Research Report
  • [Presentation] Line spectrum representation of neural signals recorded from behaving rats for brain-machine in- terfaces2013

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      35th Annual Intl. Conf. of IEEE EMBS
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2013 Final Research Report
  • [Presentation] On-board Neural Processor on Vehicular BMI for Rat toward Long-term Operation2013

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      BCI Meet- ing 2013
    • Place of Presentation
      Pacific Grove, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] On-board Neural Processor on Vehicular BMI for Rat toward Long-term Operation2013

    • Author(s)
      Osamu Fukayama, Masataka Yokota, Ryosuke Nakanishi, Takafumi Suzuki, Kunihiko Mabuchi
    • Organizer
      BCI Meeting 2013
    • Place of Presentation
      Pacific Grove, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Line spectrum representation of neural signals recorded from behaving rats for brain-machine interfaces2013

    • Author(s)
      Osamu Fukayama, Mitsuhiro Takano, Takafumi Suzuki, Kunihiko Mabuchi
    • Organizer
      35th Annual Intl. Conf. of the IEEE EMBS
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 末梢感覚入力に同期した慢性的大脳皮質刺激装置によるラット脳機能の局所変化誘発に関する検討2013

    • Author(s)
      中西良介、横田将尭、深山理、鈴木隆文、満渕邦彦
    • Organizer
      平成 25 年電気学会 電子・情報・システム部門大会
    • Place of Presentation
      北見工業大学(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 車体状 BMI ラットカー 2013: 無線自走化と皮質可塑性誘導の試み2013

    • Author(s)
      深山理、横田将尭、中西良介、高野光浩、鈴木隆文、満渕邦彦
    • Organizer
      Motor Control 研究会 2013
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bi-directional interfacing on motor nervous system with RatCar2013

    • Author(s)
      Osamu Fukayama, Mitsuhiro Takano, Ryosuke Nakanishi, Masataka Yokota, Takafumi Suzuki, Kunihiko Mabuchi
    • Organizer
      計測自動制御学会 ライフエンジニアリング部門シンポジウム 2013
    • Place of Presentation
      慶応大学(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Study on functional changes of neural activity induced by intracortical microstimulation triggered with physical activity2013

    • Author(s)
      Masataka Yokota, Ryosuke Nakanishi, Osamu Fukayama, Takafumi Suzuki, Kunihiko Mabuchi
    • Organizer
      計測自動制御学会 ライフエンジニアリング部門シンポジウム 2013
    • Place of Presentation
      慶応大学(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Automatic Locomotion-triggered Intracortical stimulating system for a rat2013

    • Author(s)
      Osamu Fukayama, Masataka Yokota, Ryosuke Nakanishi, Takafumi Suzuki, Kunihiko Mabuchi
    • Organizer
      Society for Neuroscience Annual Meeting 2013
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Built-in neural interface and processor on RatCar toward robust motor control2013

    • Author(s)
      Osamu Fukayama, Ryosuke Nakanishi, Masataka Yokota, Takafumi Suzuki, and Kunihiko Mabuchi
    • Organizer
      脳と心のメカニズム 第13回冬のワークショップ
    • Place of Presentation
      ルスツリゾート, 北海道
    • Related Report
      2012 Research-status Report
  • [Presentation] 歩行時の予備緊張の検出と認知した視空間の推定に関する研究2013

    • Author(s)
      内田 翔太,星野 隆行,我妻 玲,深山 理,満渕 邦彦
    • Organizer
      平成25年 電気学会 医用・生体工学研究会
    • Place of Presentation
      東京大学, 東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 音響入力に応じた自動微小電流刺激によるラット大脳皮質の活動変化に関する研究2013

    • Author(s)
      樋口 卓哉,中西 良介,深山 理,満渕 邦彦
    • Organizer
      平成25年 電気学会 医用・生体工学研究会
    • Place of Presentation
      東京大学, 東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Exoskeletal Limbs Device for a Rat to Assist Locomo- tion Controlled by Neural Signals based on RatCar System2012

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      IEEE EMB / CAS / SMC Workshop on Brain-Machine-Body Inter- faces
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2012-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] RatCar : A while-body neuromuscular locomotion prosthetic device with exoskeletal robotic limbs for a rat2012

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      6th Intl. Conf. on Soft Computing and Intelligent Systems & 13th Intl. Symposium on Advanced Intelligent Systems
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Final Research Report
  • [Presentation] LFPと発火頻度情報の併用による中枢神経信号の解析手法に関する基礎的研究2012

    • Author(s)
      横田将尭, 深山理, ほか
    • Organizer
      平成24年電気学会電子・情報・システム部門大会
    • Place of Presentation
      弘前大学(青森県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 微小電気刺激によるラット中枢神経活動への影響に関する基礎的検討-末梢中枢同期刺激を用いた神経活動変化誘発への試み-2012

    • Author(s)
      中西良介, 深山理, ほか
    • Organizer
      平成24年電気学会電子・情報・システム部門大会
    • Place of Presentation
      弘前大学(青森県)
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of exoskeletal robotic limbs for a rat con- trolled by neural signals based on a vehic- ular neuro-robotic platform RatCar2012

    • Author(s)
      Osamu Fukayama, et al
    • Organizer
      34th Annual Intl. Conf. of IEEE EMBS
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] ノイズ環境下における音響特徴量を用いた神経発火活動の検出および弁別に関する検討2012

    • Author(s)
      深山 理,鈴木 隆文,満渕 邦彦
    • Organizer
      第51回 日本生体医工学会
    • Place of Presentation
      福岡国際会議場, 福岡県
    • Related Report
      2012 Research-status Report
  • [Presentation] 車体型 BMI RatCar を基盤とする神経工学実験系の構成と展開2012

    • Author(s)
      深山 理,高野 光浩,中西 良介,鈴木 隆文,満渕 邦彦
    • Organizer
      第6回 Motor Control 研究会
    • Place of Presentation
      岡崎コンファレンスセンター, 愛知県
    • Related Report
      2012 Research-status Report
  • [Presentation] Exoskeletal Limbs Device for a Rat to Assist Locomotion Controlled by Neural Signals based on RatCar System2012

    • Author(s)
      Osamu Fukayama, Takafumi Suzuki, and Kunihiko Mabuchi
    • Organizer
      IEEE EMB/CAS/SMC Workshop on Brain-Machine-Body Interfaces
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of exoskeletal robotic limbs for a rat controlled by neural signals based on a vehicular neuuro-robotic platform RatCar2012

    • Author(s)
      Osamu Fukayama, Hiroshi Otsuka, Ryuta Hashimoto, Takafumi Suzuki, and Kunihiko Mabuchi
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 微小電気刺激によるラット中枢神経活動への影響に関する基礎的検討 ―末梢中枢同期刺激を用いた神経活動変化誘発への試み―2012

    • Author(s)
      中西 良介,深山 理,鈴木 隆文,満渕 邦彦
    • Organizer
      平成24年 電気学会 電子・情報・システム部門大会
    • Place of Presentation
      弘前大学, 青森県
    • Related Report
      2012 Research-status Report
  • [Presentation] LFP と発火頻度情報の併用による中枢神経信号の解析手法に関する基礎的研究2012

    • Author(s)
      横田 将尭,深山 理,鈴木 隆文,満渕 邦彦
    • Organizer
      平成24年 電気学会 電子・情報・システム部門大会
    • Place of Presentation
      弘前大学, 青森県
    • Related Report
      2012 Research-status Report
  • [Presentation] Study of motion estimation using signal from spinal nerve root in rat2012

    • Author(s)
      Naoto Ebine, Osamu Fukayama, Takafumi Suzuki, and Kunihiko Mabuchi
    • Organizer
      第27回 生体・生理工学シンポジウム
    • Place of Presentation
      北海道大学, 北海道
    • Related Report
      2012 Research-status Report
  • [Presentation] Estimation of joint angle from EMG signal by using model represents joint stiffness2012

    • Author(s)
      Akihiro Morita, Tatsuya Haga, Osamu Fukayama, Takafumi Suzuki, and Kunihiko Mabuchi
    • Organizer
      第27回 生体・生理工学シンポジウム
    • Place of Presentation
      北海道大学, 北海道
    • Related Report
      2012 Research-status Report
  • [Presentation] RatCar: A whole-body neuromuscular locomotion prosthetic device with exoskeletal robotic limbs for a rat2012

    • Author(s)
      Osamu Fukayama, Ryosuke Nakanishi, Hiroshi Otsuka, Takafumi Suzuki, and Kunihiko Mabuchi
    • Organizer
      The 6th International Conference on Soft Computing and Intelligent Systems and the 13th International Symposium on Advanced Intelligent Systems
    • Place of Presentation
      神戸国際会議場, 兵庫県
    • Related Report
      2012 Research-status Report
  • [Remarks] 東京大学 情報理工学系研究科システム情報第七研究室(満渕・星野研究室)

    • URL

      http://www.mels.ipc.i.u-tokyo.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] Mabuchi Laboratory (mels)

    • URL

      http://www.mels.ipc.i.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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