Molecular mechanism of sarcopenia development by impairment of satellite cell functions

• Project/Area Number: 24700706
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: KUROSAKA Mitsutoshi 聖マリアンナ医科大学, 医学部, 助教 (40553970)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 骨格筋 / 筋サテライト細胞 / 筋再生 / 細胞内情報伝達系 / サルコペニア

Outline of Final Research Achievements

We examined the sarcopenia-induced physiological active substance on satellite cell function in vitro and in vivo.The results demonstrated that activation of TRPV1 by CAP did not change myoblast proliferation, whereas it regulates myoblast fusion through interleukin-4 (IL-4).

Research Products

• [Journal Article] Icing at early stage depresses skeletal muscle regeneration. (2013)
  • Author(s): Ito T., Fujiya H., Goto K., Ogura Y., Kurosaka M., Yatabe K., Kishiro S., Yoshida A., Yoshioka H., Terauchi K., Beppu M., Funabashi T., Akema T., Musha H. I
  • Journal Title: Journal of St. Marianna University Volume: 4 Pages: 61-67
  • Peer Reviewed
• [Journal Article] Interleukin-6-induced satellite cell proliferation is regulated through induction of signal downstream target Cyclin D1 of JAK2/STAT3 signaling pathway (2013)
  • Author(s): Mitsutoshi Kurosaka, Shuichi Machida
  • Journal Title: Cell Proliferation Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Exercise and skeletal muscle regeneration (2012)
  • Author(s): Mitsutoshi Kurosaka, Shuichi Machida
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 1 Pages: 537-540
  • NAID: 10031158986
• [Presentation] TRPV1チャネルは骨格筋再生と筋サテライト細胞分化を調節する (2015)
  • Author(s): 黒坂光寿，小倉裕司，舩橋利也， 明間立雄
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県 神戸市）
  • Year and Date: 2015-03-21 – 2015-03-24
• [Presentation] 筋サテライト細胞におけるTRPV1チャネルの役割りとその機序の解明 (2014)
  • Author(s): 黒坂光寿，小倉裕司，舩橋利也， 明間立雄
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎県 長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] Alterations In HDACs Expressions In Response To Endurance Training In Rat Plantaris Muscle. (2014)
  • Author(s): Yoshihara T,Kurosaka M,Kakigi R,Takamine Y,Machida S,Sugiura T,Naito H.
  • Organizer: American College of Sports Medicine annual meeting
  • Place of Presentation: Indianapolis, USA
  • Year and Date: 2014-05-27 – 2014-05-31
• [Presentation] The role of JAK2/STAT3 signaling pathway in immobilization-induced muscle atrophy. (2013)
  • Author(s): Kurosaka M., Ogura Y., Fujiya H., Kishiro S., Ito T., Funabashi T., Akema T.
  • Organizer: 34th Annual Meeting International Gravitational Physiology
  • Place of Presentation: 愛知県
• [Presentation] 筋サテライト細胞における温度依存性TRPチャネルの発現と機能の検討. (2013)
  • Author(s): 黒坂光寿、小倉裕司、舩橋利也、明間立雄
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京都
• [Presentation] 骨格筋損傷に対する冷却の影響～損傷後の冷却時期による検討～. (2013)
  • Author(s): 伊藤龍登, 藤谷博人, 後藤勝正, 小倉裕司, 黒坂光寿, 木城 智, 谷田部かなか, 別府諸兄, 舩橋利也, 明間立雄, 武者春樹
  • Organizer: 第28 回日本整形外科基礎学術集会
  • Place of Presentation: 千葉県
• [Presentation] 筋損傷・再生過程におけるJAK2/STAT3経路の役割 (2013)
  • Author(s): 黒坂光寿，小倉裕司, 舩橋利也、明間立雄
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京都
• [Presentation] 高濃度IL-6はJAK2/STAT3/SOCS3系を介して筋サテライト細胞の増殖を負に制御する (2012)
  • Author(s): 黒坂光寿，町田修一
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 岐阜県