Effect of amino acid ingestion on removing metabolic waste products from skeletal muscles for enhancing second wind during exercise

• Project/Area Number: 24700717
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: University of Fukui (2013-2014); Fukui National College of Technology (2012)
• Principal Investigator: YAMADA Takayoshi 福井大学, 教育地域科学部, 講師 (60413770)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 栄養学

Outline of Final Research Achievements

This study aimed to clarify the passive uptake of urea cycle-related amino acids into the mitochondria from the cytosol in skeletal muscle cells during exercise. In particular, we examined the relationship between the passive uptake of urea cycle-related amino acids and expression levels of ornithine transporter. We also evaluated the differences in ornithine transporter expression levels in each tissue. We found no relationship between the amount of passive uptake of urea cycle-related amino acids and expression levels of ornithine transporter between tissues. Similarly, no relationship was found between the amount of passive uptake of urea cycle-related amino acids and expression levels of ornithine transporter in the same tissues. Our results suggest that passive uptake of urea cycle-related amino acids into the mitochondria is not under the simple relationship between volume and reaction.