Influence of antioxidant supplementation on muscle atrophy following anterior cruciate ligament reconstruction
| Project/Area Number |
24700719
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | University of Yamanashi (2015)
防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工学群) (2012-2014) |
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Principal Investigator |
ANDO Daisuke 山梨大学, 総合研究部, 准教授 (10447708)
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| Research Collaborator |
HAGINO Tetsuo
OCHIAI Satoshi
SENGA Shinya
YAMASHITA Takashi
TSUKAZAKI Satoshi
SUGIURA Takao
MIHARA Masahiko
KONISHI Yu
KOYAMA Katsuhiro
KIUCHI Masataka
DOBASHI Shohei
FUJIMOTO Kosuke
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 前十字靭帯 / 筋萎縮 / 酸化ストレス / 抗酸化物質 / α-リポ酸 / リハビリテーション / 骨格筋萎縮 / ACL / 炎症 / 前十字靱帯 |
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| Outline of Final Research Achievements |
The purpose of this study was to evaluate the influence of α-lipoic acid (LA) supplementation on muscle atrophy following anterior cruciate ligament (ACL) reconstruction. A randomized controlled trial was conducted in subjects undergoing ACL surgery, who were randomly assigned to either: (1) LA (n=10), or (2) placebos (n=10). Subjects took supplements twice daily for 1 day prior to and up to 4 weeks after surgery. Quadriceps muscle volume was measured on magnetic resonance imaging (MRI). Muscle atrophy of quadriceps was apparent in both groups. However, LA supplementation did not inhibit muscle atrophy. Following ACL surgery, inflammation and muscle damage increased in both groups.
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Report
(5 results)
Research Products
(1 results)
