| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The purpose of this study was to evaluate the influence of α-lipoic acid (LA) supplementation on muscle atrophy following anterior cruciate ligament (ACL) reconstruction. A randomized controlled trial was conducted in subjects undergoing ACL surgery, who were randomly assigned to either: (1) LA (n=10), or (2) placebos (n=10). Subjects took supplements twice daily for 1 day prior to and up to 4 weeks after surgery. Quadriceps muscle volume was measured on magnetic resonance imaging (MRI). Muscle atrophy of quadriceps was apparent in both groups. However, LA supplementation did not inhibit muscle atrophy. Following ACL surgery, inflammation and muscle damage increased in both groups.
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