Effects of blood mineral levels on extracellular antioxidant defense system

• Project/Area Number: 24700741
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: KAMEZAKI Fumihiko 産業医科大学, 医学部, 講師 (40535225)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ミネラル / 細胞外スーパーオキシドジスムターゼ / 酸化ストレス / 鉄 / マグネシウム / 血漿ミネラル濃度

Research Abstract

In a total of 809 middle-aged Japanese male workers, we examined the hypothesis that a decrease level of blood mineral has an important role on the dysfunction of extracellular antioxidant defense system. This study demonstrated no statistically significant correlations between blood levels of mineral such as iron and magnesium and extracellular superoxide dismutase, a major antioxidant in the cardiovascular system. Further examinations are needed to elucidate effects of blood mineral levels on the extracellular antioxidant defense system.

Research Products

• [Journal Article] Plasma levels of nitric oxide metabolites are markedly reduced in normotensive males with electro- cardiographically determined left ventricular hypertrophy (2014)
  • Author(s): 亀崎文彦、筒井正人、高橋正雄、園田信成、久保達彦、藤野善久、足立哲夫、安部治彦、竹内正明、真弓俊彦、尾辻豊
  • Journal Title: Hypertension Volume: (in press)
  • Peer Reviewed
• [Journal Article] ICU入室中の心房細動の予防・治療 (2014)
  • Author(s): 亀崎文彦、安部治彦、真弓俊彦
  • Journal Title: INTENSIVIST Volume: 6巻 Pages: 237-244
  • URL: http://www.medsi.co.jp/books/products/detail.php?product_id=3374
  • Peer Reviewed
• [Journal Article] Plasma levels of nitric oxide metabolites are markedly reduced in normotensive males with electrocardiographically determined left ventricular hypertrophy (2014)
  • Author(s): 亀崎文彦、筒井正人、高橋正雄、園田信成、久保達彦、藤野善久、足立哲夫、安部治彦、竹内正明、真弓俊彦、尾辻豊
  • Journal Title: Hypertension Volume: -
  • Peer Reviewed
• [Journal Article] Association of seasonal variation in the prevalence of metabolic syndrome with insulin resistance. (2013)
  • Author(s): Kamezaki F, Sonoda S, Nakata S, Muraoka Y, Okazaki M, Tamura M, Abe H, Tekeuchi M, Otsuji Y.
  • Journal Title: Hypertens Res. Volume: 36(5) Issue: 5 Pages: 398-402
  • DOI: 10.1038/hr.2012.197
  • Peer Reviewed
• [Journal Article] メタボリックシンドローム有病率の季節変動とインスリン抵抗性の関連 (2013)
  • Author(s): 亀崎文彦、園田信成、尾辻豊
  • Journal Title: 血圧 Volume: 20巻 Pages: 986-987
  • URL: http://www.sentan.com/cgi-bin/db_n.cgi?mode=view_backno&no=985
• [Journal Article] Proposed Cutoff Level of Waist Circumference in Japanese Men: Evaluation by Homeostasis Model Assessment of Insulin Resistance Levels (2012)
  • Author(s): 亀崎文彦、園田信成、中田靖、樫山国宣、村岡秀崇、岡崎昌博、田村雅仁、安部治彦、竹内正明
  • Journal Title: Internal Medicine Volume: 51 Issue: 16 Pages: 2119-2124
  • DOI: 10.2169/internalmedicine.51.7235
  • NAID: 130002062291
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Presentation] Proposed cutoff level of waist circumference in middle-aged Japanese men : evaluation by plasma leptin levels (2014)
  • Author(s): 亀崎文彦
  • Organizer: 第78回日本循環器学会学術集会・総会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2014-03-22
• [Presentation] Significant impact of self-reported eating speed on the prevalence of metabolic syndrome and plasma adiponectin level (2013)
  • Author(s): 亀崎文彦
  • Organizer: American Heart Association Scientific Sessions 2013
  • Place of Presentation: Dallas Convention Center (Dallas、USA)
  • Year and Date: 2013-11-18
• [Presentation] Reduced plasma levels of nitric oxide metabolites in normo- tensive middle-aged men with electrocardiographically determined left ventricular hypertrophy (2013)
  • Author(s): 亀崎文彦
  • Organizer: European Society of Cardiology Congress 2013
  • Place of Presentation: Amsterdam RAI(Amsterdam、Netherland)
  • Year and Date: 2013-09-01
• [Presentation] 細胞外スーパーオキシドジスムターゼの経気管的遺伝子導入はラットにおけるモノクロタリン誘発性肺高血圧症を軽減する (2013)
  • Author(s): 亀崎文彦
  • Organizer: 第13回日本NO学会学術集会
  • Place of Presentation: 沖縄県医師会館(沖縄)
  • Year and Date: 2013-06-28
• [Presentation] Plasma levels of nitric oxide metabolites are markedly reduced in normotensive individuals with electrocardiographically determined left ventricular hypertrophy (2012)
  • Author(s): 亀崎文彦
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: LA Convention Center (LA、USA)
  • Year and Date: 2012-11-05
• [Presentation] 低下したアディポネクチン濃度はメタボリックシンドロームの季節変動を予測する (2012)
  • Author(s): 亀崎文彦
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウェスティンナゴヤキャッスル(名古屋)
  • Year and Date: 2012-09-20
• [Presentation] Proposed cutoff level of waist circumference in middle-aged Japanese men: evaluation by plasma leptin levels
  • Author(s): 亀崎文彦
  • Organizer: 第78回日本循環器学会学術集会・総会
  • Place of Presentation: 東京国際フォーラム (東京)
• [Presentation] Reduced plasma levels of nitric oxide metabolites in normotensive middle-aged men with electrocardiographically determined left ventricular hypertrophy
  • Author(s): 亀崎文彦
  • Organizer: European Society of Cardiology Congress 2013
  • Place of Presentation: Amsterdam RAI （Amsterdam、Netherland）
• [Presentation] 細胞外スーパーオキシドジスムターゼの経気管的遺伝子導入はラットにおけるモノクロタリン誘発性肺高血圧症を軽減する
  • Author(s): 亀崎文彦
  • Organizer: 第１３回日本NO学会学術集会
  • Place of Presentation: 沖縄県医師会館 (沖縄)
• [Presentation] 正常血圧男性における心電図上の左室肥大と血漿NOx濃度の関係
  • Author(s): 亀崎文彦, 園田信成, 竹内正明, 尾辻豊
  • Organizer: 第28回福岡循環器フォーラム
  • Place of Presentation: ホテル日航福岡（福岡市）
• [Presentation] 低下したアディポネクチン濃度はメタボリックシンドロームの季節変動を予測する
  • Author(s): 亀崎文彦, 園田信成, 竹内正明, 尾辻豊
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウェスティンナゴヤキャッスル（名古屋市）
• [Presentation] Plasma levels of nitric oxide metabolites are markedly reduced in normotensive individuals with electrocardiographically determined left ventricular hypertension
  • Author(s): Kamezaki F, Tsutsui M, Adachi T, Takahashi M, Sonoda S, Takeuchi M, Otsuji Y
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: LA Convention Center (LA, USA)