Effect of Mycobacterium Bovis Bacillus Calmette–Guérin on metabolic syndrome.
| Project/Area Number |
24700755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
INAFUKU Masashi 琉球大学, 熱帯生物圏研究センター, 研究員 (90457458)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂肪肝 / インスリン抵抗性 / 小胞体ストレス / BCG菌 / 生活習慣病 / 結核 |
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| Outline of Final Research Achievements |
Tuberculosis (TB) was strongly associated with neighborhood poverty in the developed countries. To analyze influence of systemic inflammatory response to metabolic syndrome,we inoculated an attenuated vaccine strain of Mycobacterium bovis Bacillus Calmette-Gurin (BCG) into leptin-deficient ob/ob mice. BCG administration significantly decreased a homeostasis model assessment of insulin resistance. Hepatic lipid accumulation and macrovesicular steatosis were markedly alleviated, and the hepatic lipogenesis was significantly decreased in the BCG injected mice. We also exposed human hepatocellular carcinoma HepG2 cells to palmitate, which enhanced endoplasmic reticulum stress and impaired insulin sensitivity.BCG treatment ameliorated both of these detrimental events.This study therefore suggested that BCG administration suppressed development of nonalcoholic fatty liver disease, at least partly, by inhibiting lipogenesis and alleviating fatty acid-induced insulin resistance in the liver.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] nduction of ssDNA-binding autoantibody secreating B cell immunity during murine malaria infection is a critical part of the protective immune responses.2013
Author(s)
Mannoor, K., Li, C., Inafuku, M., Taniguchi, T., Sato, Y., Watanabe, H.
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Journal Title
Immunobiology
Volume: 218
Issue: 1
Pages: 10-20
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-obesity activity of Peucedanum japonicum Thunb Extract on obese diabetic animal model C57BL/6J Ham Slc-ob/ob mice.2012
Author(s)
Nukitrangsan, N., Okabe, T., Toda, T., Inafuku, M., Iwasaki, H., and Oku, H.
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Journal Title
International journal of life science and medical research.
Volume: 2(2)
Pages: 28-34
Related Report
Peer Reviewed
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[Journal Article] Protective function of an unconventional γδ T cell subset against malaria infection in apoptosis inhibitor deficient mice.2012
Author(s)
Li, C., Mannoor, M.K., Inafuku, M., Taniguchi, T., Inamine, Y., Miyazaki, T., and Watanabe, H.
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Journal Title
Cellular Immunology.
Volume: 279(2)
Issue: 2
Pages: 151-159
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Peucedanum japonicum Thunb Extract on High-fat Diet-induced Obesity and Gene Expression in Mice2012
Author(s)
Nukitrangsan, N., Okabe, T., Toda, T., Inafuku, M., Iwasaki, H., and Oku, H.
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Journal Title
Journal of oleo science.
Volume: 61(2)
Pages: 89-101
NAID
Related Report
Peer Reviewed
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