| Project/Area Number |
24700755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
INAFUKU Masashi 琉球大学, 熱帯生物圏研究センター, 研究員 (90457458)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂肪肝 / インスリン抵抗性 / 小胞体ストレス / BCG菌 / 生活習慣病 / 結核 |
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| Outline of Final Research Achievements |
Tuberculosis (TB) was strongly associated with neighborhood poverty in the developed countries. To analyze influence of systemic inflammatory response to metabolic syndrome,we inoculated an attenuated vaccine strain of Mycobacterium bovis Bacillus Calmette-Gurin (BCG) into leptin-deficient ob/ob mice. BCG administration significantly decreased a homeostasis model assessment of insulin resistance. Hepatic lipid accumulation and macrovesicular steatosis were markedly alleviated, and the hepatic lipogenesis was significantly decreased in the BCG injected mice. We also exposed human hepatocellular carcinoma HepG2 cells to palmitate, which enhanced endoplasmic reticulum stress and impaired insulin sensitivity.BCG treatment ameliorated both of these detrimental events.This study therefore suggested that BCG administration suppressed development of nonalcoholic fatty liver disease, at least partly, by inhibiting lipogenesis and alleviating fatty acid-induced insulin resistance in the liver.
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