Effect of voluntary exercise on rat hypothalamic Sirt1
| Project/Area Number |
24700764
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
KAWAKAMI Shinya 新潟医療福祉大学, 健康科学部, 助教 (60410271)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | Sirt1 / 視床下部 / 運動療法 / 摂食行動 / 内臓脂肪 / 摂食量調節 / 肥満予防 / 運動処方 |
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| Outline of Final Research Achievements |
Exercise has a temporary effect on food intake. The NAD-dependent deacetylase Sirt1 is considered to be a factor that regulates food intake through the hypothalamus. The aim of the present study was to determine whether voluntary wheel exercise regulates individual physiology through hypothalamic Sirt1 in rats and to investigate the underlying mechanism.
The results revealed that voluntary exercise did not influence food intake via hypothalamic Sirt1 in rats. However, it was suggested that hypothalamic Sirt1 was involved in the metabolism of visceral fat when a high-fat diet was ingested and in the regulation of food intake when energy intake was reduced. Therefore, this suggests that hypothalamic Sirt1 contributes to the maintenance of the physiological robustness of an individual during a change in nutritional conditions by regulating the accumulation and consumption of energy. This function may be improved by voluntary exercise.
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Report
(4 results)
Research Products
(1 results)
