| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
|---|
| Outline of Final Research Achievements |
Exercise has a temporary effect on food intake. The NAD-dependent deacetylase Sirt1 is considered to be a factor that regulates food intake through the hypothalamus. The aim of the present study was to determine whether voluntary wheel exercise regulates individual physiology through hypothalamic Sirt1 in rats and to investigate the underlying mechanism.
The results revealed that voluntary exercise did not influence food intake via hypothalamic Sirt1 in rats. However, it was suggested that hypothalamic Sirt1 was involved in the metabolism of visceral fat when a high-fat diet was ingested and in the regulation of food intake when energy intake was reduced. Therefore, this suggests that hypothalamic Sirt1 contributes to the maintenance of the physiological robustness of an individual during a change in nutritional conditions by regulating the accumulation and consumption of energy. This function may be improved by voluntary exercise.
|
