Research on physical activity and exercise for the treatment of diabetes with a focus on fatty liver

• Project/Area Number: 24700771
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Prefectural University of Kumamoto (2013); National Institute of Health and Nutrition (2012)
• Principal Investigator: YOSHIMURA Eiichi 熊本県立大学, 環境共生学部, 講師 (70613214)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脂肪肝 / 食事制限 / 有酸素運動 / 介入研究 / 糖代謝 / エネルギー代謝 / 内臓脂肪 / 糖尿病

Research Abstract

The aim of the present study was to evaluate the effect of calorie restriction-induced weight loss, with or without aerobic exercise, on liver fat. Thirty-three adults were divided into calorie restriction (CR; n = 18) or CR and aerobic exercise (CR+Ex; n = 15) groups. Target energy intake was 25 kcal/kg of ideal body weight. The CR+Ex group had a targeted exercise time of 300 min/wk or more at lactate threshold intensity for 12 weeks. Reductions in body weight and visceral fat were not statistically different between groups. Liver fat decreased significantly in both groups, with no difference between groups. Calorie restriction-induced weight loss, with or without aerobic exercise, may provide an effective reduction in liver fat in adults. In addition, the results demonstrated that there were no additional benefits relating to liver fat and liver enzymes when aerobic exercise was prescribed together with calorie restriction (Yoshimura et al. J Obesity 2014).

Research Products

• [Journal Article] Lifestyle intervention involving calorie restriction with or without aerobic exercise training improves liver fat in adults with visceral adiposity (2014)
  • Author(s): E Yoshimura, H Kumahara, T Tobina, T Matsuda, M Ayabe, A Kiyonaga, K Anzai, Y Higaki, H Tanaka
  • Journal Title: J Obesity Volume: 2014 Pages: 197216-197216
  • DOI: 10.1155/2014/197216
  • Peer Reviewed / Open Access
• [Journal Article] Aerobic Exercise Attenuates the Loss of Skeletal Muscle during Energy Restriction in Adults with Visceral Adiposity (2014)
  • Author(s): Yoshimura E, Kumahara H, Tobina T, Matono S, Ayabe M, Kiyonaga A, Higaki Y, Anzai K, Tanaka H
  • Journal Title: Obesity Facts Volume: 7(1) Issue: 1 Pages: 26-35
  • DOI: 10.1159/000358576
  • Peer Reviewed
• [Journal Article] 東日本大震災被災者健康調査の質問票における身体活動関連項目の妥当性および再現性の検討 (2014)
  • Author(s): 吉村英一,髙田和子,長谷川祐子,村上晴香,野末みほ,猿倉薫子,中出麻紀子,窪田哲也,三好美紀,坪田(宇津木)恵,井上真理子,由田克士,奥田奈賀子,宮地元彦,笠岡(坪山)宜代,西信雄,横山由香里,八重樫由美,坂田清美,小林誠一郎,徳留信寛
  • Journal Title: 岩手公衆衛生学会誌 Volume: 25(2) Pages: 7-14
  • NAID: 10031168563
• [Journal Article] Understanding of sodium content labeled on food packages by Japanese people (2014)
  • Author(s): Okuda N, Nishi N, Ishikawa-Takata K, Yoshimura E, Horie S, Nakanishi T, Sato Y, Takimoto H
  • Journal Title: Hypertens Res Volume: 37 Issue: 5 Pages: 467-471
  • DOI: 10.1038/hr.2013.149
  • Peer Reviewed
• [Journal Article] Effects of rapid weight loss and regain on body composition and energy expenditure. (2013)
  • Author(s): Sagayama H, Yoshimura E, Yamada Y, Ichikawa M, Ebine N, Higaki Y, Kiyonaga A, Tanaka H.
  • Journal Title: Applied physiology, nutrition, and metabolism. Volume: 39 Issue: 1 Pages: 21-27
  • DOI: 10.1139/apnm-2013-0096
  • Peer Reviewed
• [Journal Article] Relationship of Living Conditions With Dietary Patterns Among Survivors of the Great East Japan Earthquake (2013)
  • Author(s): Nishi N, Yoshimura E, Ishikawa-Takata K, Tsuboyama-Kasaoka N, Kubota T, Miyachi M, Tokudome S, Yokoyama Y, Sakata K, Kobayashi S, Ogawa A
  • Journal Title: Journal of Epidemiology Volume: 23 Issue: 5 Pages: 376-381
  • DOI: 10.2188/jea.JE20130025
  • NAID: 10031194276
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] 集団型指導と個別型指導による減量支援の効果の比較 (2013)
  • Author(s): 吉村英一,難波秀行,松田拓朗,北村美穂子
  • Journal Title: 健康支援 Volume: 15(2) Pages: 1-6
  • NAID: 40019810149
  • Peer Reviewed
• [Journal Article] Validity and reproducibility of a physical activity questionnaire used for health surveying among victims of the Great East Japan Earthquake (2013)
  • Author(s): 村上晴香,吉村英一,髙田和子,長谷川祐子,窪田哲也,笠岡(坪山)宜代,西信雄,横山由香里,八重樫由美,坂田清美,小林誠一郎,宮地元彦,徳留信寛
  • Journal Title: Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) Volume: 60 Issue: 4 Pages: 222-230
  • DOI: 10.11236/jph.60.4_222
  • NAID: 10031168563
  • ISSN: 0546-1766, 2187-8986
  • Peer Reviewed
• [Presentation] Aerobic Exercise Attenuates the Loss of Skeletal Muscle during Energy Restriction in Adults with Visceral Adiposity (2014)
  • Author(s): E Yoshimura, H Kumahara, T Tobina, T Matsuda, K Watabe, S Matono, M Ayabe, A Kiyonaga, K Anzai, Y Higaki and H Tanaka
  • Organizer: 12th Internation Congress on Obesity
• [Presentation] 有酸素運動は減量に伴う骨格筋の減少を抑制する
  • Author(s): 吉村英一,熊原秀晃,飛奈卓郎,綾部誠也,安西慶三,松田拓朗,清永明,桧垣靖樹,田中宏暁
  • Organizer: 第15回日本健康支援学会年次学術集会