Identification of microRNAs as molecular targets for the prevention and treatment of skeletal muscle atrophy

Research Project

Project/Area Number	24700772
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Applied health science
Research Institution	Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Principal Investigator	FUJITA Yasunori 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	筋萎縮 / microRNA / 骨格筋
Research Abstract	In an attempt to identify novel molecular targets for the prevention and treatment of skeletal muscle atrophy, we searched microRNAs associated with skeletal muscle atrophy using both cell culture and animal models. Our results showed that miR-503 regulated the expression of muscle atrophy-related genes and that miR-196a, whose expression was decreased in the skeletal muscle of aged rats and mice, was associated with oxidative stress response. More detailed analysis would reveal the usefulness of these microRNAs as molecular targets for skeletal muscle atrophy.

Report

(3 results)