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Investigation into the Relationship between Andropause and Sarcopenia and Establishment of the Methods to Prevent its Occurrence by the Physical Activity

Research Project

Project/Area Number 24700775
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionKochi University (2013-2014)
National Center for Geriatrics and Gerontology (2012)

Principal Investigator

YUKI ATSUMU  高知大学, 教育研究部人文社会科学系, 助教 (00623224)

Co-Investigator(Renkei-kenkyūsha) SHIMOKATA Hiroshi  名古屋学芸大学, 教授 (10226269)
ANDO Fujiko  愛知淑徳大学, 健康医療科学部, 教授 (90333393)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsNILS-LSA / DXA / テストステロン / 遊離テストステロン / 筋量減少 / 余暇身体活動 / アンドロゲン受容体遺伝子 / 四肢筋量 / 一般住民 / 縦断研究
Outline of Final Research Achievements

We assessed longitudinal relationships between baseline testosterone and muscle mass changes in Japanese men. We also examined whether physical activity inhibited the Sarcopenia caused by Andropose. Data from NILS-LSA(National Institute for Longevity Sciences, Longitudinal Study of Aging) was analyzed longitudinally. The association of the free Testosteron (T) levels with the loss of muscle mass was significant. Moreover, muscle mass was affected by serum levels of free T in middle-aged and elderly Japanese people who have the Long allele of the Androgen Receptor CAG microsatellite. The moderately physical activity (2.5-4.4METs) in leisure time inhibited the loss of muscle mass caused by Andropose.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 11 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) Remarks (3 results)

  • [Journal Article] サルコペニアの疫学 II2015

    • Author(s)
      幸 篤武, 安藤富士子, 下方浩史
    • Journal Title

      最新医学

      Volume: 70 Pages: 37-43

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Epidemiology of sarcopenia in elderly Japanese2015

    • Author(s)
      Yuki A, Ando F, Otsuka R, Matsui Y, Harada A, Shimokata H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 4 Issue: 1 Pages: 111-115

    • DOI

      10.7600/jpfsm.4.111

    • NAID

      130005130586

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women2015

    • Author(s)
      Yuki A, Ando F, Otsuka R, Shiomokata H
    • Journal Title

      Geriatr Gerontol Int

      Volume: 15(3) Issue: 3 Pages: 326-333

    • DOI

      10.1111/ggi.12278

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sex- and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese2015

    • Author(s)
      Kasai T, Ishiguro N, Matsui Y, Harada A, Takemura M, Yuki A, Kato Y, Otsuka R, Ando F, Shimokata H
    • Journal Title

      Geriatr Gerontol Int

      Volume: - Issue: 6 Pages: 700-706

    • DOI

      10.1111/ggi.12338

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle contraction and relaxation-response time in response to on or off status of visual stimulus.2014

    • Author(s)
      Yotani K., Nakamoto H., Ikudome S., Yuki A.
    • Journal Title

      J. Physiol. Anthropol.

      Volume: 33 Issue: 1 Pages: 1-4

    • DOI

      10.1186/1880-6805-33-23

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] サルコペニアの概念と診断基準2014

    • Author(s)
      幸 篤武, 安藤富士子, 下方浩史
    • Journal Title

      CLINICAL CALCIUM

      Volume: 24 Pages: 1441-1448

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Age-related changes in skeletal muscle mass among community-dwelling Japanese - a 12-year longitudinal study2014

    • Author(s)
      Shimokata H, Ando F, Yuki A, Otsuka R
    • Journal Title

      Geriatr Gerontol Int

      Volume: 14(Suppl. 1) Issue: S1 Pages: 85-92

    • DOI

      10.1111/ggi.12219

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] サルコペニアの診断と評価2014

    • Author(s)
      幸 篤武, 安藤富士子, 下方浩史
    • Journal Title

      臨床栄養

      Volume: 124 Pages: 279-285

    • Related Report
      2013 Research-status Report
  • [Journal Article] 地域在住高齢者におけるサルコペニアの実態2014

    • Author(s)
      幸 篤武, 下方浩史
    • Journal Title

      医学のあゆみ

      Volume: 248 Pages: 649-654

    • Related Report
      2013 Research-status Report
  • [Journal Article] Sex- and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese2014

    • Author(s)
      Kasai T, Ishiguro N, Matsui Y, Harada A, Takemura M, Yuki A, Kato Y, Otsuka R, Ando F, Shimokata H
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 印刷中

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between low free testosterone levels and loss of muscle mass2013

    • Author(s)
      Yuki A, Otsuka R, Kozakai R, Kitamura I, Okura T, Ando F, Shimokata H
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 1818-1818

    • DOI

      10.1038/srep01818

    • NAID

      120007136940

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 中高年者の脳萎縮を抑制する日常歩行量の解明 ~地域からの無作為抽出者を対象とした大規模縦断研究~2013

    • Author(s)
      幸 篤武, 森 あさか, 李成喆, 安藤富士子, 下方浩史
    • Journal Title

      デサントスポーツ科学

      Volume: 34 Pages: 31-39

    • NAID

      40019761283

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 地域在住中高年者のサルコペニアの有病率とその10年間の推移2013

    • Author(s)
      安藤富士子, 大塚 礼, 幸 篤武, 北村伊都子, 甲田道子, 下方浩史
    • Journal Title

      日本未病システム学会雑誌

      Volume: 19 Pages: 1-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Research relationship between light-intensity physical activity and cognitive function in a community-dwelling elderly population-an 8-year longitudinal study2013

    • Author(s)
      Lee S
    • Journal Title

      J Am Geriatr Soc

      Volume: 61 Issue: 3 Pages: 452-453

    • DOI

      10.1111/jgs.12119

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] サルコペニア, 虚弱の疫学-日本人データから2013

    • Author(s)
      幸 篤武、安藤富士子、下方浩史
    • Journal Title

      Bone Joint Nerve

      Volume: 3 Pages: 67-74

    • Related Report
      2012 Research-status Report
  • [Journal Article] Relationship between physical activity and brain atrophy progression2012

    • Author(s)
      Yuki A
    • Journal Title

      Med Sci Sports Exerc

      Volume: 44 Issue: 12 Pages: 2362-2368

    • DOI

      10.1249/mss.0b013e3182667d1d

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 日本人中高齢者における日常歩行量と全がん死亡との関連2014

    • Author(s)
      幸 篤武, 安藤富士子, 大塚 礼, 下方浩史
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sex and age related differences in muscle mass and quality determined by mid-thigh computed tomography in a middle aged and elderly Japanese population2014

    • Author(s)
      Kasai T, Matsui M, Harada A, Yuki A, Kato Y, Otsuka R, Ando F, Shimokata H
    • Organizer
      International Conference on Frailty & Sarcopenia Research
    • Place of Presentation
      HOTEL REY JUAN CARLOS 1(Barcelona, Spain)
    • Related Report
      2013 Research-status Report
  • [Presentation] Low Free Testosterone Levels are Associated with Loss of Appendicular Muscle Mass in Japanese Community-Dwelling Women2013

    • Author(s)
      Yuki A, Otsuka R, Kozakai R, Ando F, Shimokata H
    • Organizer
      18th Annual Congress of the European College of Sports Science
    • Place of Presentation
      INEFC (Barcelona, Spain)
    • Related Report
      2013 Research-status Report
  • [Presentation] Factors leading to regular exercise in community-living middle-aged and older people without regular exercise experience2013

    • Author(s)
      Kozakai R, Ando F, Kim HY, Lee S, Yuki A, Shimokata H
    • Organizer
      18th Annual Congress of the European College of Sports Science
    • Place of Presentation
      INEFC (Barcelona, Spain)
    • Related Report
      2013 Research-status Report
  • [Presentation] アンドロゲン受容体遺伝子多型とテストステロンの相互作用が中高齢男性の筋量に与える影響2013

    • Author(s)
      幸 篤武, 安藤富士子, 小坂井留美, 大塚 礼, 下方浩史
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 中高年期における握力の縦断変化の性差2013

    • Author(s)
      小坂井留美, 安藤富士子, 金興烈, 李成喆, 幸 篤武, 大塚 礼, 下方浩史
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Low Free Testosterone Levels are Associated with Loss of Appendicular Muscle Mass in Japanese Community-Dwelling Women2013

    • Author(s)
      Yuki A, Otsuka R, Kozakai R, Ando F, Shimokata H
    • Organizer
      18th Annual Congress of the European College of Sports Science
    • Place of Presentation
      Barcelona(Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] Factors leading to regular exercise in community-living middle-aged and older people without regular exercise experience2013

    • Author(s)
      Kozakai R, Ando F, Kim HY, Lee SC, Yuki A, Shimokata H
    • Organizer
      18th Annual Congress of the European College of Sports Science
    • Place of Presentation
      Barcelona(Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] 中高年男性における余暇身体活動強度と血清遊離テストステロン濃度の関連2012

    • Author(s)
      幸 篤武, Lee SC, 小坂井留美, 金 興烈, 安藤富士子, 下方浩史
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 中高齢者の歩幅と歩調に影響を与える関連要因2012

    • Author(s)
      金 興烈, Lee SC, 小坂井留美, 幸 篤武, 安藤富士子, 下方浩史
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 運動経験のない中高年者における運動習慣開始の要因2012

    • Author(s)
      小坂井留美, 安藤富士子, 金 興烈, Lee SC, 幸 篤武, 下方浩史
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 地域在住中高齢者の体力が認知機能に及ぼす影響に関する縦断的研究2012

    • Author(s)
      Lee SC, 幸 篤武, 金 興烈, 小坂井留美, 安藤富士子, 下方浩史
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 地域在住中高年者のサルコペニア有病率とその10年間の推移2012

    • Author(s)
      安藤富士子,大塚礼,幸篤武,北村伊都子,甲田道子,下方浩史
    • Organizer
      第19回日本未病システム学会学術総会
    • Place of Presentation
      金沢市
    • Related Report
      2012 Research-status Report
  • [Remarks] 国立長寿医療研究センター・老化に関する長期縦断疫学研究(NILS-LSA)モノグラフ

    • URL

      http://www.ncgg.go.jp/department/ep/nilslsa.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 国立長寿医療研究センター・老化に関する長期縦断疫学研究~モノグラフ~

    • URL

      http://www.ncgg.go.jp/department/ep/nilslsa.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 国立長寿医療研究センター・老化に関する長期縦断疫学研究~モノグラフ~

    • URL

      http://www.ncgg.go.jp/department/ep/nilslsa.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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