Study of the responsible compounds for contact dermatitis caused by the formaldehyde releasers in cosmetics

• Project/Area Number: 24700796
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General human life sciences
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: TAKAHIRO Doi 大阪府立公衆衛生研究所, 衛生化学部, 主任研究員 (90516767)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 化粧品 / 防腐剤 / 皮膚感作性 / ジアゾリジニル尿素 / イミダゾリジニル尿素 / DMDMヒダントイン / ＤＭＤＭヒダントイン

Research Abstract

We have developed the method to determine formaldehyde-releasers in cosmetics. Using the developed method, we identified unknown compounds derived from formaldehyde-releasers in cosmetics. Two common decomposition products were found from cosmetics containing imidazolidinyl urea and diazolidinylurea. These common decomposition compounds were possible causative agent of cross-reaction between imidazolidinyl urea and diazolidinyl urea.

Research Products

• [Journal Article] Simultaneous Determination of 11 Preservatives in Cosmetics by High-Performance Liquid Chromatography. (2014)
  • Author(s): Aoyama A, Doi T, Tagami T, and Kajimura K.
  • Journal Title: J. Chromatogr. Sci. Volume: 未定 Issue: 9 Pages: 1010-1015
  • DOI: 10.1093/chromsci/bmt144
  • Peer Reviewed
• [Journal Article] Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials (2012)
  • Author(s): T. Doi, A. Takeda, A. Asada, and K. Kajimura
  • Journal Title: Contact Dermatitis Volume: 67 Pages: 284-292
• [Journal Article] Quantification of 1,3-dimethylol-5,5-dimethyl- hydantoin and its decomposition products in cosmetics by high-performance liquid chromatography (2012)
  • Author(s): A. Asada, T. Doi, A. Takeda, and K. Kajimura
  • Journal Title: J Pharm Biomed Anal Volume: 67-68 Pages: 163-168
• [Journal Article] Quantification of 1,3-dimethylol-5,5-dimethylhydantoin and its decomposition products in cosmetics by high-performance liquid chromatography (2012)
  • Author(s): A. Asada, T. Doi, A. Takeda, and K. Kajimura
  • Journal Title: Journal of Pharmaceutical and Biomedical Analysis Volume: 67-68 Pages: 163-168
  • DOI: 10.1016/j.jpba.2012.04.039
  • Peer Reviewed
• [Journal Article] Simultaneous determination of 11 preservatives in cosmetics by high-performance liquid chromatography
  • Author(s): A. Aoyama, T. Doi, T. Tagami, and K. Kajimura
  • Journal Title: J Chromatogr Sci Volume: (in press)
• [Presentation] 化粧品中の1,3-ジメチロール-5,5-ジメチルヒダントインとその分解物の定量について (2013)
  • Author(s): 淺田安紀子、土井崇広、青山愛倫、武田章弘、田上貴臣、梶村計志
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 化粧品中の防腐剤一斉分析法について (2013)
  • Author(s): 青山愛倫、淺田安紀子、土井崇広、田上貴臣、梶村計志、沢辺善之
  • Organizer: 第50回全国衛生化学技術協議会年会
  • Place of Presentation: 富山
• [Presentation] 化粧品中の防腐剤一斉分析法について
  • Author(s): 青山 愛倫、淺田 安紀子、土井 崇広、田上 貴臣、梶村 計志、沢辺善之
  • Organizer: 第50回全国衛生化学技術協議会年会
  • Place of Presentation: 富山
• [Presentation] 化粧品中の1,3-ジメチロール-5,5-ジメチルヒダントインとその分解物の定量について
  • Author(s): 淺田 安紀子、土井 崇広、青山 愛倫、武田 章弘、田上 貴臣、梶村 計志
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Remarks] 化粧品中のホルムアルデヒド遊離型防腐剤とホルムアルデヒドによるアレルギー性接触皮膚炎について
  • URL: http://www.iph.pref.osaka.jp/merumaga/back/106-2.html
• [Remarks] 化粧品中のホルムアルデヒド遊離型防腐剤とホルムアルデヒドによるアレルギー性接触皮膚炎について
  • URL: http://www.iph.pref.osaka.jp/merumaga/back/106-2.html