Using Osteoimmunology, the search for food compounds which promote bone formation

• Project/Area Number: 24700805
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Aomori University of Health and Welfare
• Principal Investigator: TOSHIO Norikura 青森県立保健大学, 健康科学部, 講師 (40468111)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨免疫学 / 骨芽細胞 / 食品成分 / 骨粗鬆症 / 分化 / 糖尿病 / 破骨細胞

Outline of Final Research Achievements

Healthy bone tissue is maintained by the harmony of bone formation and bone absorption.Bone formation is carried out by osteoblasts. On the other hand, bone resorption is carried out by osteoclasts.Closely related metabolism and immunity is evident, osteoimmunology was pioneered is a new fusion region.The purpose of this study is to find food compounds having an effect of promoting bone formation from the food compound having anti-allergic activities.We found two types of food ingredients that promote the differentiation into osteeoblasts.We constructed experimental conditions to examine the effects of suppressing osteoporosis caused by diabetes.