The effect of food component on anticancer drug-induced alpha-defensin reduction in the intestine.
| Project/Area Number |
24700818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 相互作用 / 抗がん剤 / サプリメント |
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| Research Abstract |
Supplements are being used by many cancer patients to alleviate side effects of chemotherapy and therapy-related symptoms such as immune compromise. Some nutraceuticals have been approved as dietary foods for special medical purposes for cancer patients. The interactions between supplements and anticancer drugs may increase or decrease the pharmacological or toxicological actions. So, we examined the effect of interaction between anticancer drug and food constituent on the expression of alpha-defensins by using a Caco-2 cell line. We detected HD-5 and HD-6 mRNA in Caco-2 cells and evaluated the effects of FT and EGCG, one of food component, on these mRNA levels. HD-5 and HD-6 mRNA levels were decreased by exposure to FT. Production of reactive oxygen species (ROS) was induced by exposure to FT as well as hydrogen peroxide exposure, and EGCG suppressed FT-induced production of ROS. Furthermore, FT-induced decrease in HD-5 and HD-6 mRNA levels was almost completely suppressed by EGCG.
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Report
(3 results)
Research Products
(6 results)
