| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
We performed a global analysis of hepatic gene expression in rats fed a magnesium (Mg)-deficient diet for a shorter term (2 weeks or 3 days), with the result that hepatic energy metabolism was changed to a greater or lesser extend. These changes were generally similar to those in rats fed the same Mg-deficient diet for a longer term (4 weeks). Thus it is likely that overall changes in hepatic energy metabolism in rats fed the Mg-deficient diet for the longer term are already induced shortly. However, changes in some serum biochemical parameters and some hepatic gene expression in rat fed the Mg-deficient diet were different between the two administration periods. We also characterized temporal factors specific to the difference in the Mg-deficient administration periods.
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