Modulatory Effect of Vitamin C in Early Immune Response

• Project/Area Number: 24700822
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Takasaki University of Health and Welfare (2014-2015); Ochanomizu University (2012-2013)
• Principal Investigator: SONE YASUKO 高崎健康福祉大学, 公私立大学の部局等, 講師 (80452027)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 免疫応答 / 遺伝子発現 / 免疫細胞 / ビタミンC / 酸化 / 免疫 / 炎症 / HL60

Outline of Final Research Achievements

It is suggested the possibility that the supplementations of highly-concentrated vitamin C promote the generation of the anti-inflammatory autacoid. The highly-concentrated vitamin C level in this study could be carried out by intravenous injection, not by a general meal.

Research Products

• [Journal Article] Efficacy of habitual exercise for improving lipid profiles depends on the PPRAγ genotype in Japanese males. (2014)
  • Author(s): Sone Y, Hirasawa R, Ichi I, Ishikawa T, Kodama S, Sone H, Egawa S, Kawahara K, Otsuka Y, Fujiwara Y.
  • Journal Title: J Nutr Sci Vitaminol. Volume: 60 Pages: 66-70
  • NAID: 130003393767
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Changes in Fatty Acid Composition of Maiwashi (Sardine) Added with Linoleic Acid during Fermentation Process in Fish Sauce Making. (2014)
  • Author(s): Akiyama Sannomaru Y, Sanceda N, Sone Y, Kurata T, Suzuki E.
  • Journal Title: Journal of Cookery Science of Japan Volume: 47 Pages: 165-170
  • NAID: 130004587540
  • Peer Reviewed
• [Journal Article] 高脂肪摂取マウスの骨に及ぼすα-トコフェロールの影響. (2014)
  • Author(s): 曽根保子, 園田麻里子, 赤尾茉衣, 石川朋子, 市育代, 藤原葉子.
  • Journal Title: ビタミンEの進歩. Volume: 16 Pages: 28-34
  • Peer Reviewed
• [Journal Article] Changes in the phospholipid fatty acid composition of the lipid droplet during the differentiation of 3T3-L1 adipocytes. (2013)
  • Author(s): Arisawa K, Ichi I, Yasukawa Y, Sone Y, Fujiwara Y.
  • Journal Title: J Biochem Volume: 154 Issue: 3 Pages: 281-289
  • DOI: 10.1093/jb/mvt051
  • NAID: 40019769979
  • Peer Reviewed
• [Journal Article] Quality and accuracy of Internet information concerning a healthy diet. (2013)
  • Author(s): Hirasawa R, Yachi Y, Yoshizawa S, Horikawa C, Heianza Y, Sugawara A, Sone Y, Kondo K, Shimano H, Saito K, Kodama S, Sone H.
  • Journal Title: Int J Food Sci Nutr Volume: 64 Pages: 1007-1013
  • Peer Reviewed
• [Journal Article] Use of high-normal levels of hemoglobin A1C and fasting plasma glucose for diabetes screening and prediction - A meta-analysis (2013)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Hirasawa R, Yachi Y, Yoshizawa S, Tanaka S, Sone Y, Shimano H, Iida KT, Saito K, Sone H
  • Journal Title: Diabetes Metab Res Rev Volume: 29 Issue: 8 Pages: 680-92
  • DOI: 10.1002/dmrr.2445
  • Peer Reviewed
• [Journal Article] Genetic variants of the fatty acid desaturase gene cluster are associated with plasma LDL cholesterol levels in Japanese males. (2013)
  • Author(s): Sone Y, Kido T, Ainuki T, Sonoda M, Ichi I, Kodama S, Sone H, Kondo K, Morita Y, Egawa S, Kawahara K, Otsuka Y, Fujiwara Y
  • Journal Title: J Nutr Sci Vitaminol Volume: 59 Pages: 325-335
  • NAID: 40019766154
  • Peer Reviewed
• [Journal Article] 脂肪酸組成比によるSCD1活性と動脈硬化性疾患誘導性脂質プロファイルとの関連 (2013)
  • Author(s): 曽根保子, 江川重信, 河原和夫, 近藤和雄, 大塚譲, 藤原葉子
  • Journal Title: 日本臨床栄養学会誌 Volume: 35 Pages: 114-129
  • NAID: 10031190842
  • Peer Reviewed
• [Journal Article] Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysis. (2012)
  • Author(s): Kodama S, Saito K, Tanaka S, Horikawa C, Fujiwara K, Hirasawa R, Yachi Y, Sone Y, Tada Iida K, Shimano H, Ohashi Y, Yamada N, Sone H.
  • Journal Title: J Atheroscler Thromb. Volume: 19 Pages: 385-396
  • NAID: 130004444600
  • Peer Reviewed
• [Journal Article] E 同族体が高脂肪食誘導性肥満マウスの耐糖能に及ぼす影響. (2012)
  • Author(s): 近松 出穂，吉原 千寿，山下 香織，赤尾 茉衣，園田 麻里子，石川 朋子，池本真二，西川 可穂子，曽根 保子，市 育代，藤原 葉子.
  • Journal Title: ビタミン Volume: 86 Pages: 671-677
  • Peer Reviewed
• [Journal Article] Isolation and antioxidant activity of zeylaniin A, a new macrocyclic ellagitannin from Syzygium zeylanicum leaves. (2012)
  • Author(s): Nomi Y, Shimizu S, Sone Y, Tuyet MT, Gia TP, Kamiyama M, Shibamoto T, Shindo K, Otsuka Y.
  • Journal Title: J Agric Food Chem. Volume: 60 Issue: 41 Pages: 10263-10269
  • DOI: 10.1021/jf302977n
  • Peer Reviewed
• [Presentation] 脂肪酸組成比によるSCD1活性と動脈硬化性疾患誘導性脂質プロファイルとの関連. (2015)
  • Author(s): 曽根保子.
  • Organizer: 第37回日本臨床栄養学会総会.
  • Place of Presentation: 都市センターホテル(東京都千代田区)
  • Year and Date: 2015-10-02
  • Invited
• [Presentation] Effect of short-term fasting on biomarkers and status of Vitamin C in Mice. (2015)
  • Author(s): Sato Y, Suzuki E, Murai M, Sone Y, Miyake N.
  • Organizer: 12th Asian Congress of Nutrition.
  • Place of Presentation: Pacifico Yokohama (Minato Mirai, Nishi-ku, Yokohama 220-0012, Japan)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Effect of High-Fat Diet on Behavior of Ascorbic Acid in C57BL6/J Mice. (2015)
  • Author(s): Murai M, Sato Y, Sone Y, Isaka A, Nishimura C, Kogure M, Miyake N, Suzuki E.
  • Organizer: 12th Asian Congress of Nutrition.
  • Place of Presentation: Pacifico Yokohama (Minato Mirai, Nishi-ku, Yokohama 220-0012, Japan)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 微侵襲システムを用いた新規試験食の検討 (2014)
  • Author(s): 曽根保子, 江川重信, 馬場郁子,藤原葉子, 大塚譲, 河原和夫,角中ちひろ,佐藤利幸, 村田雄司.
  • Organizer: 第36回日本臨床栄養学会総会・第35回日本臨床栄養協会総会
  • Place of Presentation: ＪＰタワー ホール＆カンファレンス
  • Year and Date: 2014-10-04 – 2014-10-05
• [Presentation] 赤血球膜リン脂質のSCD1活性比と脂質代謝異常との関連 (2014)
  • Author(s): 曽根保子, 市育代, 江川重信, 河原和夫, 近藤和雄, 大塚譲,藤原葉子.
  • Organizer: 第46回日本動脈硬化学会総会･学術集会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 赤血球膜中リン脂質の脂肪酸組成と血中脂質代謝プロファイルとの関連ついて (2014)
  • Author(s): 曽根保子, 杉浦恵美, 有澤琴子, 園田麻里子, 市育代, 石川朋子,河原和夫, 大塚譲, 藤原葉子.
  • Organizer: 第68回日本栄養･食糧学会
  • Place of Presentation: 酪農学園大学
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] The association of serum lipid profile with SCD1 desaturase indices in red blood cell membranes. (2013)
  • Author(s): Sone Y, Ichi I, Kawahara K, Kondo K, Otsuka Y, Fujiwara Y.
  • Organizer: 20th International Congress of Nutrition
  • Place of Presentation: Granada Conference and Exhibition Centre
• [Presentation] オリーブ葉ポリフェノールOleuropein が糖質代謝に及ぼす影響 (2013)
  • Author(s): 池田尚悦・赤尾茉衣・園田麻里子・曽根保子・市育代・石川朋子・藤原葉子
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス
• [Presentation] 赤血球膜中リン脂質の脂肪酸組成と脂質代謝異常との関連について (2013)
  • Author(s): 曽根保子・有澤琴子・園田麻里子・市育代・河原和夫・近藤和雄・大塚譲・藤原葉子
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 脂肪酸組成比によるSCD1活性指標と動脈硬化誘導性脂質プロファイルとの関連 (2013)
  • Author(s): 曽根保子・河原和夫・近藤和雄・大塚譲・藤原葉子
  • Organizer: 第35回日本臨床栄養学会総会
  • Place of Presentation: 京都テレサ
• [Presentation] 高脂肪摂食マウスの骨に及ぼすα-トコフェロールの影響. (2013)
  • Author(s): 曽根 保子、赤尾 茉衣、園田 麻里子、齋藤 温子、石川 朋子、市 育代、藤原 葉子.
  • Organizer: 第24回ビタミンＥ 研究会
  • Place of Presentation: 東京
• [Presentation] non HDL レベル・LDL/HDL 比と赤血球膜の脂肪酸組成との関連について. (2012)
  • Author(s): 曽根 保子、園田 麻里子、河原 和夫、近藤 和雄、大塚 譲、藤原 葉子.
  • Organizer: 日本臨床栄養学会
  • Place of Presentation: 東京
• [Presentation] SCD1の一遺伝子多型は血液中脂質マーカーと赤血球膜中の推定SCD1活性と関連する. (2012)
  • Author(s): 曽根 保子、園田 麻里子、市 育代、河原 和夫、近藤 和雄、大塚 譲、藤原 葉子.
  • Organizer: 日本分子生物学会
  • Place of Presentation: 福岡
• [Book] ビタミン. 「免疫応答におけるビタミンCの生理学的役割」 (2013)
  • Author(s): 曽根保子, 藤原葉子
  • Total Pages: 4
  • Publisher: 日本ビタミン学会
• [Remarks] 研究紹介
  • URL: http://www.takasaki-u.ac.jp/p_eiyo/7994/
• [Remarks] 研究者の研究内容、および研究成果に関するwebページ
  • URL: http://researchmap.jp/7000000025/
• [Remarks] 所属研究機関が作成した研究内容、および研究成果に関するwebページ
  • URL: http://www.takasaki-u.ac.jp/p_eiyo/7994/
• [Remarks] researchmap
  • URL: http://researchmap.jp/7000000025/
• [Remarks] 所属機関webページ
  • URL: http://www.takasaki-u.ac.jp/p_eiyo/7994/
• [Remarks] J-GLOBAL
  • URL: http://jglobal.jst.go.jp/search.php
• [Remarks] ReaD & Researchmap
  • URL: http://researchmap.jp/7000000025/
• [Remarks] Research Gate
  • URL: https://www.researchgate.net/profile/Yasuko_Sone/
• [Remarks] 栄養化学研究室
  • URL: http://www.hles.ocha.ac.jp/food/eiyo-ken/sub3_3.html