Analysis of mechamisms in brain tumor stem cell regulation by polyphenol

• Project/Area Number: 24700824
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Gifu University
• Principal Investigator: IKEGAME Yuka 岐阜大学, 医学(系)研究科(研究院), 助教 (50402201)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ポリフェノール / 脳腫瘍幹細胞 / レスベラトロール / 腫瘍抑制効果 / 腫瘍幹細胞 / 分化誘導

Research Abstract

Resveratrol (RSV) is a natural polyphenolic compound, present in plants and food made from plants, that can cross the blood-brain barrier. Glioblastoma (GBM) is the most malignant primary brain tumor, which is known to have cancer stem cells (CSCs). CSCs appear to be an important cause of GBM's formidable resistance to various therapies, such as chemical agents or radiation.
In the present study, RSV's anti-tumor effects against CSCs in GBM (U87 cells) and mechanisms including Sirtuin (SIRT) genes were indicated. The results from analyses of morphological changes and expressed proteins indicated: (1) RSV can induce GBM-CSC differentiation, which could make GBM more responsive to therapies; (2) RSV's anti-tumor effects on GBM may include mechanisms related to the activation or inactivation of SIRT genes (SIRT 1, 2, 3, 6) that induce CSC differentiation, which contribute to reduction of the malignancy, and cell death.

Research Products

• [Journal Article] Progranulin, a major secreted protein of mouse adipose-derived stem cells, inhibits light-induced retinal degeneration. (2014)
  • Author(s): Tsuruma K, Yamauchi M, Sugitani S, Otsuka T, Ohno Y, Nagahara Y, Ikegame Y, Shimazawa M, Yoshimura S, Iwama T, Hara H.
  • Journal Title: Stem Cells Transl Med. Volume: 3 Issue: 1 Pages: 42-53
  • DOI: 10.5966/sctm.2013-0020
  • Peer Reviewed
• [Journal Article] Among mesenchyma1 stem ce11s : for the best therapy after ischemic stroke (2013)
  • Author(s): Ikegame Y
  • Journal Title: Stem Ce11 Research & Therapy Volume: vo1.4、No.1(Epub ahead of print) Pages: 9-9
  • Peer Reviewed
• [Journal Article] Among mesenchymal stem cells: for the best therapy after ischemic stroke. (2013)
  • Author(s): Ikegame Y.
  • Journal Title: Stem Cell Res Ther. Volume: 4
  • Peer Reviewed
• [Journal Article] Among mesenchymal stem cells: for the best therapy after ischemic stroke. (2013)
  • Author(s): Yuka Ikegame
  • Journal Title: Stem Cell Research and Therapy Volume: 4(1)
  • Peer Reviewed