| Project/Area Number |
24700828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHUTO Emi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (10512121)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | メタボリックシンドローム / 大豆イソフラボン / 慢性炎症 / 栄養免疫 |
|---|
| Research Abstract |
Metabolic syndrome is the underlying disease proceed crirical disorder, diabetes, stroke, et al. Nearly, it was reported that T cell-infiltrated in adipose tissues was regulated differentiation of macrophage, so macrophage was dictated chronic inflammation in adipose tissue and whole-body. We ever reported about immune function of soy isoflavone. In this study, we examined effect of Soy isoflavones on the inflammation in diet indused obesity mice.
Soy isoflavones were ameliorated glucose metabolism and lipid metabolism, and declining trend to accumulation of body fat. In particular, Equol was significantly inhibited expression of gene associated macrophage. Thus, it is suggested that soy isoflavone might be possible to prevent metabolic syndrome.
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