Effect of aging and lifestyle disease on protein arginine methylation and Alzheimer's disease
| Project/Area Number |
24700840
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Kochi (2014)
Okayama Prefectural University (2012-2013) |
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Principal Investigator |
SUZUKI Makiko 高知県立大学, その他部局等, 准教授 (60437001)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルギニンメチル化 / PRMT / マウス脳 / CARM1 / 加齢 / 高脂肪食 / ADMA / 糖尿病 |
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| Outline of Final Research Achievements |
5 week-old mice were assigned to two groups fed with normal diet or high-fat diet for 65 weeks. High-fat diet group was induced insulin resistance. Expression of Protein arginine methyltransferase 1 (PRMT1) were decreased by both high-fat diet and aging. Expression of CARM1, an isoform of PRMTs was decreased by aging. Although expression of Sam 68 which is a substrate for PRMT1 was not affected by high-fat diet and aging, arginine methylation of component protein of Sam 68 complex was up-regulated by both high-fat diet and aging.
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Report
(4 results)
Research Products
(3 results)
