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Curative and preventive effects of dietary lily bulb on colonic luminal environment and lifestyle-related diseases

Research Project

Project/Area Number 24700845
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionFuji Women's University

Principal Investigator

OKAZAKI Yukako  藤女子大学, 人間生活学部, 准教授 (80433415)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsユリネ / 腸内環境 / 生活習慣病 / 肝障害 / 炎症性大腸炎 / ラット / 高脂肪食 / 大腸炎 / 栄養学
Outline of Final Research Achievements

This study demonstrated that consumption of lily bulb, a traditional food in Asia, increased fecal IgA and mucins (indices intestinal immune and barrier functions), colonic fermentation, and improved intestinal microflora composition in rats fed a high-fat diet. Dietary lily bulb also reduced adipose tissue weight by increasing fecal lipid excretion. Furthermore, this study showed that consumption lily bulb may suppress liver injury and inflammatory colitis. These results suggest that lily bulb can be considered as a novel functional food for improving colonic luminal environment and preventing lifestyle-related diseases under the high-fat diet condition.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] Edible lily bulb modulates colonic barrier functions, microflora and fermentation in rats fed a high-fat diet.2014

    • Author(s)
      Yukako Okazaki, Eri Fukuda, Hideyuki Chiji, Norihisa Kato
    • Journal Title

      Journal of Nutritional Health & Food Science

      Volume: 2 Pages: 1-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Effect of dietary lily bulb on dextran sulfate sodium-induced colitis in rats fed a high-fat diet2015

    • Author(s)
      Yukako Okazaki, Eri Fukuda, Hideyuki Chiji, Norihisa Kato
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ユリネ摂取が高脂肪食摂取ラットのデキストラン硫酸ナトリウム誘導大腸炎に及ぼす影響2014

    • Author(s)
      岡崎 由佳子,福田 絵里,知地 英征,加藤 範久
    • Organizer
      第44回日本栄養・食糧学会北海道支部会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] ユリネのエタノール抽出物および抽出残渣物が高脂肪食摂取ラットの腸内環境に及ぼす影響2014

    • Author(s)
      岡崎由佳子,山口さより,平敏夫,福田絵里,知地英征,加藤範久
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 生および加熱ユリネの摂取が高脂肪食摂取ラットの大腸内環境に及ぼす影響2013

    • Author(s)
      岡崎由佳子,福田絵里,知地英征,加藤範久
    • Organizer
      日本家政学会第65回大会
    • Place of Presentation
      昭和女子大学
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Favorable effect of consumption of lily bulb on colonic luminal environment in rats fed a high-fat diet2013

    • Author(s)
      Yukako Okazaki, Eri Fukuda, Hideyuki Chiji, Norihisa Kato
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada Congress Centre, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Favorable effect of consumption of lily bulb on colonic luminal environment in rats fed a high-fat diet2013

    • Author(s)
      Yukako Okazaki, Eri Fukuda, Hideyuki Chiji, Norihisa Kato
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada (Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] ユリネ摂取が高脂肪食摂取ラットの腸内フローラと肝障害に及ぼす影響

    • Author(s)
      岡崎由佳子,山口さより,平敏夫,福田絵里,知地英征,加藤範久
    • Organizer
      第43回 日本栄養・食糧学会北海道支部会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ユリネ摂取が高脂肪食摂取ラットの腸内細菌叢およびβ-GlucuronidaseとMucinase活性に及ぼす影響

    • Author(s)
      岡崎由佳子,福田絵里,知地英征,加藤範久
    • Organizer
      第42回 日本栄養・食糧学会 北海道支部会
    • Place of Presentation
      とかちプラザ
    • Related Report
      2012 Research-status Report
  • [Presentation] 加熱処理したユリネのラット腸内環境と脂質代謝への影響

    • Author(s)
      岡崎由佳子,福田絵里,知地英征,加藤範久
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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