| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In the present study, I investigated that the effect of n-3 polyunsaturated fatty acid (n-3PUFA), DHA and EPA, on the symptoms of pulmonary arterial hypertension using monocrotaline-induced pulmonary hypertensive (PH) rats. Fish oil was orally given as a source of n-3 PUFA once a day. Continuous administration of fish oil by itself failed to prolong the survival duration and to ameliorate the right ventricular hypertrophy of PH rats. In contrast, the treatment with fish oil partially improved the vascular function of the pulmonary artery isolated from PH rats. Moreover, the treatment with fish oil tended to attenuate the expression of interleukin (IL)-18 mRNA, a cytokine belonging to the IL-1 superfamily. These results suggest the possibility that n-3PUFA acts as an adjunctive agent in PH medication.
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