Study on the effects of n-3 polyunsaturated fatty acid on the medication for pulmonary hypertension with the experimental animal model.
| Project/Area Number |
24700846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SAITO Maki 岩手医科大学, 薬学部, 助教 (40365185)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺高血圧症 / n-3系多価不飽和脂肪酸 / モノクロタリン / 脂質メディエーター / 血管平滑筋 / メカニカルストレス |
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| Outline of Final Research Achievements |
In the present study, I investigated that the effect of n-3 polyunsaturated fatty acid (n-3PUFA), DHA and EPA, on the symptoms of pulmonary arterial hypertension using monocrotaline-induced pulmonary hypertensive (PH) rats. Fish oil was orally given as a source of n-3 PUFA once a day. Continuous administration of fish oil by itself failed to prolong the survival duration and to ameliorate the right ventricular hypertrophy of PH rats. In contrast, the treatment with fish oil partially improved the vascular function of the pulmonary artery isolated from PH rats. Moreover, the treatment with fish oil tended to attenuate the expression of interleukin (IL)-18 mRNA, a cytokine belonging to the IL-1 superfamily. These results suggest the possibility that n-3PUFA acts as an adjunctive agent in PH medication.
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Report
(4 results)
Research Products
(15 results)
