| Project/Area Number |
24700850
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Jin-ai University |
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Principal Investigator |
IKEDA RYOUKO 仁愛大学, 人間生活学部, 准教授 (80352805)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 鉄欠乏性貧血 / 耐糖能異常 / β-カロテン / 酸化ストレス / 生体内相互作用 / 鉄欠乏 / βカロテン / 基礎栄養学 |
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| Outline of Final Research Achievements |
Increase of blood sugar and inflammatory cytokine was observed in the iron-deficient GK rats, model animal of type 2 diabetes mellitus. It was supposed that these phenomena were caused by the lipid peroxidation in the iron-deficiency. In this study, we examined the effect of dietary β-carotene on suppression of inflammatory cytokine and improvement of the glucose tolerance in the iron-deficient GK rats.
In the first experiment, serum adiponectin increased, and in the second experiment, serum resistin was decreased by dietary β-carotene administration. However, it was very difficult to confirm plasticity about the alteration of these adipocytokine. These results suggested that the change of beta-carotene dose participated in serum insulin-resistant factor complicatedly. To inflammatory cytokine and blood sugar, the effect of dietary β-carotene was not observed, and it was guessed that a factor except peoxidation derived impaired glucose tolerance in the iron-deficient GK rats.
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