Effect of n-3 fatty acids supplementation on hepatic phospholipid metabolism in nonalcoholic steatohepatitis.

Research Project

Project/Area Number	24700852
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Eating habits, studies on eating habits
Research Institution	Fukuyama University
Principal Investigator	MURAKAMI Yasuko 福山大学, 生命工学部, 講師 (90326413)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	NASH / 非アルコール性脂肪性肝炎 / n-3系脂肪酸 / コリン・メチオニン欠乏 / n-3系脂質 / コリンメチオニン欠乏
Research Abstract	Feeding a diet deficient in both methionine and choline (MCD) is one of the most common models of nonalcoholic steatohepatitis (NASH). We analyzed the effects of n-3 fatty acids (FA) supplementation on the hepatic phospholipids and injury in MCD fed mice. n-3 FA improved plasma transaminase levels and hepatic triglyceride accumulation in the MCD model of NASH. n-3 FA supplementation also changed liver phospholipids FA composition, not only polyunsaturated fatty acid but also saturated fatty acid.

Report

(3 results)