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The association between vitamin C intake and plasma concentration and physical function by vitamin C related DNA polymorphism

Research Project

Project/Area Number 24700860
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionYokohama City University (2014-2015)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2012-2013)

Principal Investigator

SAITO Kyoko  横浜市立大学, 医学部, 助教 (20507389)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsビタミンC / 身体機能 / 高齢者 / 運動機能 / 血中ビタミンC濃度 / SVCT1 / SVCT2 / GSTs / 高齢女性 / ビタミン関連遺伝子多型
Outline of Final Research Achievements

Recent studies suggest that vitamins AND minerals, which have antioxidant properties, enhances muscle strength and has prophylactic activity against bone fractures, osteoporosis, and decreases in physical performance. A cross-sectional study conducted in 2006 on community-dwelling elderly women suggested that high blood concentrations of vitamin C is associated with improved physical performance. This was done by conducting a follow-up survey in 2013 using the 2006 survey results as a baseline in order to provide a longitudinal analysis with a higher level of evidence.
In community-dwelling women, the concentration of blood vitamin C related well to their physical performance. The association between baseline concentration of vitamin C and seven year change in physical function showed that maximal walking speed significantly increased.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (1 results)

  • [Journal Article] A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women : Comparison in healthy Japanese subjects.2012

    • Author(s)
      Saito K., Yokoyama T., Yoshida H., Kim H., Shimada H., Yoshida Y., Iwasa H., Shimizu Y., Kondo Y., Handa S., Maruyama N., Ishigami A. and Suzuki T.
    • Journal Title

      J. Gerontol. A Biol. Sci. Med. Sci.

      Volume: 67(3) Issue: 3 Pages: 295-301

    • DOI

      10.1093/gerona/glr174

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 地域在宅高齢者におけるベースライン時の血中VC濃度は7年後の運動機能に影響を及ぼすか?2015

    • Author(s)
      齋藤京子、河合恒、平野浩彦、藤原佳典、井原一成、吉田英世、大渕修一、近藤嘉高、石神昭人
    • Organizer
      第57回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 地域在宅高齢者における血中ビタミンE濃度と身体・運動機能との関連2013

    • Author(s)
      齋藤京子、 河合恒、 平野浩彦、 藤原佳典、 小島基永、 井原一成、 吉田英世、 大渕修一、 丸山直紀、 石神昭人
    • Organizer
      第55回日本老年医学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Relationship between plasma carotenoid levels and physical performance among Japanese elderly2013

    • Author(s)
      Kyoko Saito, Akihito Ishigami, Yuki Kishimoto, Naoki Maruyama, Shuichi Oubuchi, Kim Miji
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      韓国
    • Related Report
      2013 Research-status Report
  • [Presentation] Relationship between BMI and lifestyle factors of elderly Japanese people in medical home care2013

    • Author(s)
      Kyoko Saito, Rika Otuka, Masafumi Kuzuya, Kayoko Maeda, Hisayuki Miura
    • Organizer
      66th GSA Annual scitntific meeting
    • Place of Presentation
      ニューオリンズ
    • Related Report
      2013 Research-status Report
  • [Presentation] 地域在宅高齢者における血中ビタミンE濃度と身体・運動機能との関連2013

    • Author(s)
      齋藤京子、河合恒、平野浩彦、藤原佳典、小島基永、井原一成、吉田英世、大渕修一、丸山直紀、石神昭人
    • Organizer
      第55回日本老年医学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] Relationship between plasma carotenoid levels and physical performance among Japanese elderly2013

    • Author(s)
      Kyoko Saito, Akihito Ishigami, Yuki Kishimoto, Naoki Maruyama, Shuichi Oubuchi, Kim Miji
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Seoul
    • Related Report
      2012 Research-status Report
  • [Book] Aging: Oxidative Stress and Dietary Antioxidants-Vitamin c and physical performance in the elderly-2014

    • Author(s)
      Kyoko Saito, Hosoi Erika, Ishigami Akihito, Yokoyama Tetsuji
    • Total Pages
      328
    • Publisher
      Elsevier
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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