| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The prevention or modulation of immune response through the regulation of Th2 type helper T cell differentiation is recently demonstrated to attenuate symptoms which related to allergy. Here, we investigated the effect of brown rice extracts (BRE) on IFN-γ production from mice splenocytes. The treatment of BRE dose-dependently increased IFN-γ. In order to determine the active component, we separated BRE by ultrafiltration. High molecular weight fraction enhanced IFN-γ production. We further examined whether oral administration of BRE could have a beneficial effect on immune system in ovalbumin (OVA)-immunized mice. The oral administration of BRE dose-dependently induced IFN-γ production by splenocytes. Total and OVA-specific IgE in serum of mice, which were administrated BRE, was lower than that of the OVA-immunized mice. These results suggest that BRE might improve the Th1/Th2 balance toward Th1 dominance.
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