A study on rice extract potentiating intestinal immune system for prevention of allergy.
Project/Area Number |
24700863
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits, studies on eating habits
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Research Institution | Shujitsu University (2014-2015) 岡山県農林水産総合センター生物科学研究所 (2012-2013) |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 食品機能 / 米 / 腸管免疫 / パイエル板 / Th1/Th2 / 生理活性 / 免疫学 / IgA |
Outline of Final Research Achievements |
The prevention or modulation of immune response through the regulation of Th2 type helper T cell differentiation is recently demonstrated to attenuate symptoms which related to allergy. Here, we investigated the effect of brown rice extracts (BRE) on IFN-γ production from mice splenocytes. The treatment of BRE dose-dependently increased IFN-γ. In order to determine the active component, we separated BRE by ultrafiltration. High molecular weight fraction enhanced IFN-γ production. We further examined whether oral administration of BRE could have a beneficial effect on immune system in ovalbumin (OVA)-immunized mice. The oral administration of BRE dose-dependently induced IFN-γ production by splenocytes. Total and OVA-specific IgE in serum of mice, which were administrated BRE, was lower than that of the OVA-immunized mice. These results suggest that BRE might improve the Th1/Th2 balance toward Th1 dominance.
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Report
(5 results)
Research Products
(11 results)
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[Presentation] 酒粕由来ペプチドの肝障害抑制作用2015
Author(s)
川上賀代子,加藤春華, 守谷智恵,戸羽光世, 平本和義, 藤田明子,川上晃司,畑中唯史,洲崎悦子, 坪井誠二
Organizer
54回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
Place of Presentation
高知市文化プラザかるぽーと(高知県高知市)
Year and Date
2015-10-31
Related Report
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