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A study on rice extract potentiating intestinal immune system for prevention of allergy.

Research Project

Project/Area Number 24700863
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionShujitsu University (2014-2015)
岡山県農林水産総合センター生物科学研究所 (2012-2013)

Principal Investigator

Kawakami Kayoko  就実大学, 薬学部, 助教 (00505935)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords食品機能 / 米 / 腸管免疫 / パイエル板 / Th1/Th2 / 生理活性 / 免疫学 / IgA
Outline of Final Research Achievements

The prevention or modulation of immune response through the regulation of Th2 type helper T cell differentiation is recently demonstrated to attenuate symptoms which related to allergy. Here, we investigated the effect of brown rice extracts (BRE) on IFN-γ production from mice splenocytes. The treatment of BRE dose-dependently increased IFN-γ. In order to determine the active component, we separated BRE by ultrafiltration. High molecular weight fraction enhanced IFN-γ production. We further examined whether oral administration of BRE could have a beneficial effect on immune system in ovalbumin (OVA)-immunized mice. The oral administration of BRE dose-dependently induced IFN-γ production by splenocytes. Total and OVA-specific IgE in serum of mice, which were administrated BRE, was lower than that of the OVA-immunized mice. These results suggest that BRE might improve the Th1/Th2 balance toward Th1 dominance.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013 2012

All Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 酒粕ペプチドのアセトアミノフェン誘導肝障害抑制作用2016

    • Author(s)
      川上賀代子,加藤春華, 垣内紗恵子, 守谷智恵,藤田明子,川上晃司,畑中唯史,洲崎悦子, 坪井誠二
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 米由来ペプチドのアセトアミノフェン誘導肝障害抑制作用2015

    • Author(s)
      川上賀代子,守谷智恵,藤田明子,川上晃司,畑中唯史,洲崎悦子, 坪井誠二
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酒粕由来ペプチドの肝障害抑制作用2015

    • Author(s)
      川上賀代子,加藤春華, 守谷智恵,戸羽光世, 平本和義, 藤田明子,川上晃司,畑中唯史,洲崎悦子, 坪井誠二
    • Organizer
      54回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protective effects of rice peptides on acetaminophen-induced hepatotoxicity in mice2015

    • Author(s)
      Kayoko Kawakami, Chie Moritani, Misugi Uraji, Yoshikazu Inoue, Akiko Fujita, Koji Kawakami, Tadashi Hatanaka, Etsuko Suzaki, Seiji Tsuboi
    • Organizer
      ACN2015 (12th Asian Congress of Nutrition)
    • Place of Presentation
      Pacifico Yokohama (Yokohama, Kanagawa)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酒粕由来ペプチドの抗酸化作用について2014

    • Author(s)
      川上賀代子,守谷智恵,戸羽光世,平本和義,裏地美杉,井上良計,藤田明子,川上晃司,畑中唯史,坪井誠二
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
    • Place of Presentation
      広島県広島市 広島国際会議場
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Antioxidant effect of rice peptides via elevation of the intracellular glutathione levels2014

    • Author(s)
      Kayoko Kawakami, Chie Moritani, Misugi Uraji, Yoshikazu Inoue, Akiko Fujita, Koji Kawakami, Tadashi Hatanaka, Seiji Tsuboi
    • Organizer
      International Conference on Food for Health in Niigata 2014
    • Place of Presentation
      新潟県新潟市 新潟コンベンションセンター
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of brown rice extracts on immune responce in OVA-immunized mice.2013

    • Author(s)
      Kayoko Kawakami, Hitomi Mori, Misugi Uraji, Tadashi Hatanaka, Hideyuki Ito
    • Organizer
      ISNFF 2013 Annual Conference & Exhibition
    • Place of Presentation
      Howard Civil Service International House, Taipei, Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] 玄米抽出物の免疫調節作用に関する研究(1)2012

    • Author(s)
      川上賀代子、森ひとみ、熊谷祐也、臼木博一、向原隆文、畑中唯史、伊東秀之
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学川内北キャンパス、宮城
    • Related Report
      2012 Research-status Report
  • [Presentation] 玄米抽出物の免疫調節作用に関する研究(2)2012

    • Author(s)
      森ひとみ、川上賀代子、畑中唯史、伊東秀之
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学川内北キャンパス、宮城
    • Related Report
      2012 Research-status Report
  • [Presentation] Immunoregulatory effects of brown rice extracts.2012

    • Author(s)
      Kayoko Kawakami, Hitomi Mori, Misugi Uraji, Masayo Kimura, Tadashi Hatanaka, and Hideyuki Ito
    • Organizer
      Bioactive Okayama 2012
    • Place of Presentation
      50th Anniversary Hall of Okayama University, Okayama
    • Related Report
      2012 Research-status Report
  • [Presentation] Brown rice extracts enhance intestinal immune functions in mice.2012

    • Author(s)
      Kayoko Kawakami, Hitomi Mori, Misugi Uraji, Masayo Kimura, Tadashi Hatanaka, and Hideyuki Ito
    • Organizer
      The 6th International Niigata Symposium on Diet and Health
    • Place of Presentation
      Niigata Convention Center, Niigata
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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