A novel role of oncogenic RAS in gene silencing
| Project/Area Number |
24700951
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Carcinogenesis
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| Research Institution | Tohoku University |
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Principal Investigator |
FUNAYAMA Ryo 東北大学, 医学(系)研究科(研究院), 助教 (20452295)
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| Research Collaborator |
NAGASHIMA Takeshi 東北大学, 大学院医学系研究科, 助教 (80443000)
HOSOGANE Masaki 東北大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エピジェネティクス / ヒストン / 発がん / RAS / 転写 / サイレンシング / ｓｈRNA / スクリーニング / shRNA |
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| Research Abstract |
RAS-MAPK signaling regulates cell growth and survival. It is abnormally activated in cancer cells and represses transcription of tumor-suppressive genes to enhance tumorigenesis of the cells. In this study, I investigated the molecular mechanism of RAS-mediated transcriptional repression. RAS-MAPK signaling increases the amount of a histone modification in transcriptionally repressed genes. The alteration of the histone modification occurs after alteration of transcription, suggesting that the histone modification functions to maintain transcriptionally repressed state. Furthermore, I identified three chromatin proteins, which are required for transcriptional repression.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] RNA sequencing-based identification of aberrant imprinting in cloned mice.2014
Author(s)
Okae H, Matoba S, Nagashima T, Mizutani E, Inoue K, Ogonuki N, Chiba H, Funayama R, Tanaka S, Yaegashi N, Nakayama K, Sasaki H, Ogura A, Arima T.
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Journal Title
Hum Mol Genet.
Volume: 23
Issue: 4
Pages: 992-1001
DOI
Related Report
Peer Reviewed
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[Journal Article] Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers2013
Author(s)
Ninomiya, M., Kondo, Y., Funayama, R., Nagashima, T., Kogure, T., Kakazu, E., Kimura, O., Ueno, Y., Nakayama, K., Shimosegawa, T.
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Journal Title
PloS one
Volume: 8
Issue: 6
Pages: e66086-e66086
DOI
Related Report
Peer Reviewed
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[Journal Article] Exome sequencing identifies a novel TTN mutation in a family with hereditary myopathy with early respiratory failure2013
Author(s)
Izumi R, Niihori T, Aoki Y, Suzuki N, Kato M, Warita H, Takahashi T, Tateyama M, Nagashima T, Funayama R, Abe K, Nakayama K, Aoki M, Matsubara Y
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Journal Title
J Hum Genet
Volume: 58(5)
Issue: 5
Pages: 259-66
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Y-chromosome-linked B- and NK-cell deficiency in mice2013
Author(s)
Sun SL, Horino S, Itoh-Nakadai A, Kawabe T, Asao A, Takahashi T, So T, Funayama R, Kondo M, Saitsu H, Matumoto N, Nakayama K, and Ishii N
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Journal Title
J. Immunol.
Volume: 190
Issue: 12
Pages: 6209-6220
DOI
Related Report
Peer Reviewed
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[Journal Article] Gain-of-Function Mutations in RIT1 Cause Noonan Syndrome, a RAS/MAPK Pathway Syndrome2013
Author(s)
Aoki Y, Niihori T, Banio T, Okamoto N, Mizuno S, Kurosawa K, Ogata T, Takada F, Yano M, Ando T, Hoshika T, Barnett C, Ohashi H, Kawame H, Hasegawa T, Okutani T, Nagashima T, Hasegawa S, Funayama R, Nagashima T Nakayama K, Inoue S, Watanabe Y, Oeura T, Matsubara Y
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Journal Title
The American Journal of Human Genetics
Volume: Volume 93, Issue 1
Issue: 1
Pages: 173-180
DOI
Related Report
Peer Reviewed
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[Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012
Author(s)
Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
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Journal Title
Journal of clinical microbiology
Volume: 50
Issue: 3
Pages: 857-866
DOI
Related Report
Peer Reviewed
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[Presentation] Change of trimethylation of H3K27 occurs after Ras-mediated transcriptional regulation2012
Author(s)
Hosogane, M., Funayama, R., Nishida, Y., Nagashima, T., Nakayama, K.
Organizer
Winter Camp of GCOE 2012, Tohoku University Global COE for Conquest of Signal Transduction Diseases with"Network Medicine"
Place of Presentation
仙台
Year and Date
2012-02-04
Related Report
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