| Project/Area Number |
24700965
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAHASHI Atsushi 東京大学, 医学(系)研究科(研究院), 助教 (00624496)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子生物学 / がん / シグナル伝達 / タンパク質リン酸化／脱リン酸化 / 遺伝子発現制御 / 細胞内シグナル伝達 / タンパク質チロシンリン酸化・脱リン酸化 / Wntシグナル経路 / Hippoシグナル経路 / チロシンリン酸化 |
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| Research Abstract |
In the 1st fiscal year ended March 2013, (1) We found a cancer-derived point mutant of parafibromin functionally mimicking the tyrosine-dephosphorylated parafibromin, which promotes the Wnt signaling pathway through forming a complex with beta-catenin. (2) We identified a nuclear tyrosine kinase that can elevate the tyrosine-phosphorylation of parafibromin.
In the 2nd fiscal year ended March 2014, (3) We found that SHP2 physically interacts with transcriptional co-activators YAP and TAZ, components of the cell-density sensing Hippo signaling pathway. We revealed the YAP/TAZ-dependent regulatory mechanism of the nuclear accumulation of SHP2, which promotes the Wnt signaling pathway through tyrosine-dephosphorylation of parafibromin.
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