Regulation of EGF signaling transduction in breast cancer-initiating cells and their niches

• Project/Area Number: 24700968
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: The University of Tokyo
• Principal Investigator: MIZUTANI ANNA 東京大学, 医学(系)研究科(研究院), 特任研究員 (30615159)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: がん幹細胞 / 乳がん / 癌幹細胞

Research Abstract

Recently cancer-initiating cells have been considered to be important targets in chemotherapy. Our data using breast cancer cell lines shows transforming growth factor (TGF)-beta signaling is involved in cancer-initiating like cell maintenance in addition to epidermal growth factor (EGF) and fibroblast growth factor (FGF) signaling. We previously showed that epithelial splicing regulatory protein (ESRP) was transcriptionally down-regulated by TGF-beta. ESRPs are involved in mRNA splicing widely. We investigated the regulatory mechanisms of ESRPs. Here we obtained the data which could be a clue to understand the regulatory mechanism of ESRPs.

Research Products

• [Journal Article] An adaptor protein complex of FRS2beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation (2013)
  • Author(s): 後藤 典子
  • Journal Title: Cancer Sci Volume: 104 Issue: 3 Pages: 345-352
  • DOI: 10.1111/cas.12086
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] An E3 ligase regulates ESRPs (2013)
  • Author(s): Anna Mizutani, Daizo Koinuma, Kohei Miyazono
  • Organizer: TGF-betaファミリーシグナル国際共同研究拠点第3回国際シンポジウム
  • Place of Presentation: 愛媛、松山(ポスター発表)
• [Presentation] Regulatory mechanism of ESRP1 and ESRP2 proteins (2013)
  • Author(s): 水谷アンナ、鯉沼代造、宮園浩平
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神奈川、横浜(ポスター発表)
• [Presentation] Regulatory mechanism of ESRP1 and ESRP2 proteins (2013)
  • Author(s): 水谷アンナ、鯉沼代造、宮園浩平
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] An E3 ligase regulates ESRPs (2013)
  • Author(s): Mizutani A, Koinuma D and Miyazono K
  • Organizer: TGF-bファミリーシグナル国際共同研究拠点第3回国際シンポジウム
  • Place of Presentation: 松山