The functional analysis of novel long non-coding RNA regulating p53
| Project/Area Number |
24700975
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ノンコーディングRNA / 細胞増殖 / がん / p53 / 長鎖ノンコーディングRNA |
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| Research Abstract |
In this study, we aimed the functional analysis of long non-coding RNA, POLOP (Positive regulator lncRNA of p53). We found that POLOP highly expresses in human osteosarcoma cells. The expression of POLOP was induced by the treatment of etoposide and forced expression of H-RASG12V. The depletion of POLOP in human osteosarcoma cells decreased cell growth. These results suggest that POLOP promotes the cell growth of human osteosarcoma cells.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice2012
Author(s)
Sayuri Suzuki, Hirotaka Fukasawa, Taro Misaki, Akashi Togawa, Naro Ohashi, Kyoko Kitagawa, Yojiro Kotake, Ning Liu, Hiroyuki Niida, Keiko Nakayama , Keiichi I. Nakayama, Tatsuo Yamamoto and Masatoshi Kitagawa
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[Presentation] Skp2ノックアウトマウスで見られた腎障害の軽減はSkp2-p27ダブルノックアウトマウスで解除される
Author(s)
鈴木小由里,深澤洋敬,三崎太郎,戸川証,大橋温,北川恭子,神武洋二郎,Liu Ning,丹伊田浩行,山本龍夫,北川雅敏
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡国際会議場・マリンメッセ福岡（福岡市）
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