Tumorigenesis triggered by the misregulation of cell polarity associated with cell cycle

• Project/Area Number: 24700980
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kumamoto University
• Principal Investigator: KIKUCHI Koji 熊本大学, 生命科学研究部, 助教 (70457290)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 細胞運動 / 前後極性 / 上皮極性 / 微小管動態 / MAP7ファミリー / Wnt5aシグナル / Dvl2

Research Abstract

The establishment and maintenance of cell polarity has a crucial role in multiple biological processes from chemotaxis to embryogenesis, and the abnormality of cell polarity promotes tumorigenesis. It is believed that cytoskeletal network between microtubule (MT) and filamentous actin plays an important role for the establishment and maintenance of cell polarity. However, molecular mechanisms of the cytoskeletal network still remain unclear. Here, we found that MT co-sedimented proteins, which we have previously identified, are involved in the establishment of cell polarity by regulating the cytoskeletal network.

Research Products

• [Journal Article] Structure-specific endonucleases Xpf and Mus81 play overlapping but essential roles in DNA repair by homologous recombination (2013)
  • Author(s): Kikuchi, K., Narita, T., Van, P.T, Iijima, J., Hirota, K., Keka, I.S., Mohiuddin, M., Okawa, K., Hori, T., Fukagawa, T., Essers, J., Kanaar, R., Whitby, M.C., Sugasawa, K., Taniguchi, Y., Kitagawa, K., and Takeda, S
  • Journal Title: Cancer Res Volume: 73 Pages: 4362-4371
  • Peer Reviewed
• [Journal Article] Structure-specific endonucleases Xpf and Mus81 play overlapping but essential roles in DNA repair by homologous recombination. (2013)
  • Author(s): Kikuchi K, Narita T, Pham 〓, Iij〓 J, Hirota K, Islam SK, Mohiuddin M, Okawa K, Bori T, Fukagama T, Essers J, Kanser R, Whithy NC, Sugasawa K, Taniguchi T, Kitagawa K. Takeda S.
  • Journal Title: Cancer Res. Volume: (in press) Issue: 14 Pages: 6917-6929
  • DOI: 10.1158/0008-5472.can-12-3154
  • Peer Reviewed
• [Journal Article] Wnt5a signaling controls cytokinesis by correctly positioning ESCRT-III at the midbody (2012)
  • Author(s): Fumoto, K., Kikuchi, K., Gon, H., and Kikuchi, A
  • Journal Title: J. Cell Sci. Volume: 125 Pages: 4822-4832
  • Peer Reviewed
• [Journal Article] Wnt5a signaling controls cytokinesis by correctly positioning ESCRT-III at the midbody. (2012)
  • Author(s): Fumoto, K.*, Kikuchi, K.*, Gon, H., and Kikuchi, A. (*: equal contribution)
  • Journal Title: Journal of Cell Science Volume: 125 Pages: 4822-4832
  • DOI: 10.1242/jcs.108142
  • Peer Reviewed
• [Presentation] MAP7 family proteins organize the cytoskeletal network by regulating microtubule dynamics in cell polarity (2013)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: 第36回日本分子生物学会年会
• [Presentation] Novel functions of Wnt signaling pathways in mitotic progression (2013)
  • Author(s): 菊池浩二、麓勝己、菊池章
  • Organizer: 3rd GDRI French Japanese Cancer Meeting
  • Place of Presentation: Hotel Mercure Toulouse Compans Caffarelli(フランス・トゥールーズ)
• [Presentation] siRNA Screening Reveals the Involvement of MAP7 Family in Cell Polarity (2013)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: 平成24年度文部科学省新学術領域研究「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
  • Place of Presentation: 学術総合センター一橋講堂(東京都千代田区)
• [Presentation] siRNA Screening Reveals the Involvement of MAP7 Family in Cell Polarity (2013)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: The 23rd CDB Meeting "Building multicellular systems from Cellular Cross-Talk"
  • Place of Presentation: 理化学研究所再生・発生科学総合研究センター(神戸市)
• [Presentation] MAP7 family proteins organize the cytoskeletal network by regulating microtubule dynamics in cell polarity. (2013)
  • Author(s): 菊池浩二
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド（神戸市）
• [Presentation] Novel functions of Wnt signaling pathways in mitotic progression. (2013)
  • Author(s): 菊池浩二
  • Organizer: 3rd GDRI French Japanese Cancer Meeting
  • Place of Presentation: Hotel Mercure Toulouse Compans Caffarelli（フランス・トゥールーズ）
• [Presentation] siRNA Screening Reveals the Involvement of MAP7 Family in Cell Polarity. (2013)
  • Author(s): 菊池浩二
  • Organizer: 平成24年度文部科学省新学術領域研究「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
  • Place of Presentation: 学術総合センター一橋講堂（東京都千代田区）
• [Presentation] siRNA Screening Reveals the Involvement of MAP7 Family in Cell Polarity. (2013)
  • Author(s): 菊池浩二
  • Organizer: The 23rd CDB Meeting "Building multicellular systems from Cellular Cross-Talk"
  • Place of Presentation: 理化学研究所再生・発生科学総合研究センター（神戸市）
• [Presentation] MAP7 family proteins are involved in cell polarization by regulating the cytoskeletal network (2012)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: 第65回日本薬理学会西南部会
  • Place of Presentation: 熊本大学薬学部(熊本市)
  • Year and Date: 2012-11-23
• [Presentation] MAP7ファミリーによる細胞極性の制御機構 (2012)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: 第85会日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡市)
• [Presentation] MAP7ファミリーによる細胞極性の制御機構 (2012)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡市)
• [Presentation] siRNA screening reveals the involvement of MAP7 family in cell polarity (2012)
  • Author(s): 菊池浩二、中西宏之
  • Organizer: 新学術領域研究「がん研究分野の特性等を踏まえた支援活動」平成24年度がん若手研究者ワークショップ
  • Place of Presentation: 蓼科グランドホテル滝の湯(長野県茅野市)
• [Presentation] MAP7ファミリーによる細胞極性の制御機構 (2012)
  • Author(s): 菊池浩二
  • Organizer: 第85会日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] MAP7ファミリーによる細胞極性の制御機構 (2012)
  • Author(s): 菊池浩二
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] siRNA screening reveals the involvement of MAP7 family in cell polarity. (2012)
  • Author(s): 菊池浩二
  • Organizer: 新学術領域研究「がん研究分野の特性等を踏まえた支援活動」平成24年度がん若手研究者ワークショップ
  • Place of Presentation: 蓼科グランドホテル滝の湯（長野県茅野市）
• [Presentation] MAP7 family proteins are involved in cell polarization by regulating the cytoskeletal network.
  • Author(s): 菊池浩二
  • Organizer: 第65回日本薬理学会西南部会
  • Place of Presentation: 熊本大学薬学部（熊本市）
• [Remarks] 本研究室のホームページ
  • URL: http://www.medphas.kumamoto-u.ac.jp/research/bunya/8.html
• [Remarks] Researchmapの個人ページ
  • URL: http://researchmap.jp/read0147459/
• [Remarks] Researchgateの個人ページ
  • URL: https://www.researchgate.net/profile/Koji_Kikuchi/
• [Remarks] Researchmapの個人ページ
  • URL: http://researchmap.jp/read0147459/
• [Remarks] Researchgateの個人ページ
  • URL: https://www.researchgate.net/profile/Koji_Kikuchi/
• [Remarks] 所属研究機関が作成した研究室紹介のページ
  • URL: http://www.medphas.kumamoto-u.ac.jp/research/bunya/8.html
• [Remarks] ReaD & Researchmapの個人ページ
  • URL: http://researchmap.jp/read0147459/
• [Remarks] 所属研究機関が作成した研究室紹介のページ
  • URL: http://www.medphas.kumamoto-u.ac.jp/research/bunya/8.html