Elucidation of the pathogenic mechanism of, and construction of therapeutic strategy for, Neurofibromatosis type 1-associated tumors via TCTP
| Project/Area Number |
24700981
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経線維腫 / NF1 / TCTP / Neurofibromin / プロテオミクス |
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| Research Abstract |
Neurofibromatosis type-1 (NF1) is an inherited disorder that presents various pathological conditions including benign neurofibromas and malignant tumors. Due to the lack of information on the molecular mechanism of NF1-associated tumor pathogenesis or biomarkers/therapeutic targets, a radical treatment for NF1 tumors has not been established. In this study, we evaluated whether the novel NF1-associated protein, translationally controlled tumor protein (TCTP), could be a novel biomarker and therapeutic target for NF1-associated tumors. We found that TCTP expression level correlated with their malignancy and contributes to NF1-associated tumor cell growth. Collective to our findings, it is expected that a diagnostic method and therapeutic strategies targeting TCTP for NF1-associated tumors has been developed.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in NF1 disease model cells.2013
Author(s)
Hirayama M, Kobayashi D, Mizuguchi S, Morikawa T, Nagayama M, Midorikawa U, Wilson MM, Nambu AN, Yoshizawa AC, Kawano S, Araki N.
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Journal Title
Molecular & Cellular Proteomics
Volume: 28
Issue: 5
Pages: 1377-94
DOI
Related Report
Peer Reviewed
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[Journal Article] Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin aV2013
Author(s)
Akiko Niibori-Nambu, Uichi Midorikawa, Souhei Mizuguchi, Takuichiro Hide, Minako Nagai,Yoshihiro Komohara, Megumi Nagayama, Mio Hirayama, Daiki Kobayashi, Nobuyuki Tsubota,Tatsuya Takezaki, Keishi Makino, Hideo Nakamura, Motohiro Takeya, Junichi Kuratsu, Norie Araki
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Journal Title
PLoS ONE
Volume: 8(5)
Issue: 5
Pages: e59558-e59558
DOI
Related Report
Peer Reviewed
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[Journal Article] Glioma initiaing cells form a differentiation niche via the induction of extra cellular matrices and integrin alpha V2013
Author(s)
Niibori-Nambu A, Midorikawa U, Mizuguchi S, Hide T, Nagai M, Komohara Y, Nagayama M, Hirayama M, Kobayashi D, Tsubota N, Takezaki T, Makino K, Nakamura H, Takeya M, Kuratsu J and Araki N
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Integrated Proteomics identified Novel Activation of Dynein IC2-GR-COX-1 Signaling by Suppression of NF1 Tumor Suppressor Gene Product, Neurofibromin, in Neuronal Cells.2013
Author(s)
Kobayashi D, Hirayama M, Mizuguchi S, Morikawa T, Nagayama M, Midorikawa U, Wilson-Morifuji M, Nambu-Niibori A, Yoshizawa AC, Kawano S, Araki N
Organizer
HUPO 12th Annual World Congress
Place of Presentation
Pacifico Yokohama (Yokohama)
Related Report
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[Presentation] An Integrated Proteomics for Extracting Molecular Target of Malignant Gliomas2013
Author(s)
Araki N, Morikawa T, Mizuguchi S, Kobayashi D, Nambu AN, Midorikawa U, Hirayama M, Morifuji MW, Kawano S, Nakamura H, Kuratsu J
Organizer
HUPO 12th Annual World Congress
Place of Presentation
Pacifico Yokohama (Yokohama)
Related Report
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[Presentation] A Quick Profiling System for Cancer Marker Proteins with Diverse Post-Translational Modifications by a Fully Automated 2DE Device, Auto-2D2013
Author(s)
Nishimura M, Midorikawa U, Nagayama M, Kobayashi D, Hirayama M, Murakami Y, Wada Y, Imamura T, Unuma Y, Araki N
Organizer
HUPO 12th Annual World Congress
Place of Presentation
Pacifico Yokohama (Yokohama)
Related Report
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[Presentation] Integrated Proteomics Identified the Differentiation Niche Induced by Glioma Stem Cells2013
Author(s)
Nambu AN, Midorikawa U, Mizuguchi S, Hide T, Nagai M, Komohara Y, Nagayama M, Hirayama M, Kobayashi D, Nakamura H, Takeya M, Kuratsu J, Araki N
Organizer
HUPO 12th Annual World Congress
Place of Presentation
Pacifico Yokohama (Yokohama)
Related Report
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[Presentation] Integrated Proteomics Identified Translationally Controlled Tumor Protein as a Biological Target for Neurofibroma and Malignant Peripheral Nerve Sheath Tumors2012
Author(s)
Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson-morifuji M, Ihn h, Takeya M, Kuramochi A, Araki N.
Organizer
HUPO 11th Annual World Congress
Place of Presentation
Hynes Convention Center, Boston, US
Related Report
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[Presentation] An integrated proteomics by iPEACH, a new application, identified novel activated signal cascades in chemotherapy resistant malignant gliomas2012
Author(s)
Araki N, Mizugushi S, Morikawa T, kawano S, Yamaguchi A, Kobayashi D, Hirayama M, Midorikawa U, Nakamura H, Kuratsu J.
Organizer
HUPO 11th Annual World Congress
Place of Presentation
Hynes Convention Center, Boston, US
Related Report
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