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A cancer stem cells search and pathogenesis elucidation of AITL

Research Project

Project/Area Number 24700982
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionNagoya City University

Principal Investigator

ITO Asahi  名古屋市立大学, 医学(系)研究科(研究院), 助教 (00571762)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsAITL / NOGマウス / モデルマウス / 悪性リンパ腫 / がん幹細胞
Research Abstract

We established the AITL model mouse which transplanted fresh patient samples of AITL to the NOG mouse which was an immunodeficiency mouse. This model reflected various condition of human AITL very well. We could not observe a gamma globulin production and the growth of B lymphocyte, plasma cells reproduced with tumor cells of AITL in a process that AITL fresh tumor cells were transfused into NOG mouse and made transplantation, and only tumor cells were found to grow. In other words, as for that we could observe various pictures of AITL, a thing only the first model mouse which we transplanted was found first. Only the strong tumor cells main body of the power to engraft more in a process to make transplantation survived it, and it was thought that other part were lost.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Angioimmunoblastic T-cell lymphoma mice model.2013

    • Author(s)
      Sato F
    • Journal Title

      Leuk Res.

      Volume: 37 Issue: 1 Pages: 21-7

    • DOI

      10.1016/j.leukres.2012.09.009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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