A cancer stem cells search and pathogenesis elucidation of AITL

Research Project

Project/Area Number	24700982
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor biology
Research Institution	Nagoya City University
Principal Investigator	ITO Asahi 名古屋市立大学, 医学(系)研究科(研究院), 助教 (00571762)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	AITL / NOGマウス / モデルマウス / 悪性リンパ腫 / がん幹細胞
Research Abstract	We established the AITL model mouse which transplanted fresh patient samples of AITL to the NOG mouse which was an immunodeficiency mouse. This model reflected various condition of human AITL very well. We could not observe a gamma globulin production and the growth of B lymphocyte, plasma cells reproduced with tumor cells of AITL in a process that AITL fresh tumor cells were transfused into NOG mouse and made transplantation, and only tumor cells were found to grow. In other words, as for that we could observe various pictures of AITL, a thing only the first model mouse which we transplanted was found first. Only the strong tumor cells main body of the power to engraft more in a process to make transplantation survived it, and it was thought that other part were lost.