Characterization of the oncogenic activity of TRB3 by regulating p53 activation
| Project/Area Number |
24700983
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Nagoya City University |
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Principal Investigator |
INOUE Yasumichi 名古屋市立大学, 薬学研究科(研究院), 准教授 (10450579)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | p53 / TRB3 / がん / 細胞周期 / アポトーシス / シグナル伝達 |
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| Research Abstract |
TRB3 is originally identified as a kinase-like molecule in response to ER stress. While TRB3 has the substrate-binding domain, the consensus amino acids for protein phosphorylation are missing. Therefore, TRB3 is believed to act as a scaffold protein regulating various signal transducers positively and negatively. In this project, we have demonstrated that TRB3 interacts with p53 and attenuates the biological functions of p53. Also, it is revealed that TRB3 is a novel checkpoint reguators when cells are exposed to ER stress.
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Report
(3 results)
Research Products
(44 results)
