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Functional analysis for TRA2B, as novel target of cancer therapy

Research Project

Project/Area Number 24700984
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionSaitama Medical University

Principal Investigator

WADA Satoru  埼玉医科大学, 医学部, 助教 (80438837)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords癌遺伝子 / 選択的スプライシング / TRA2B / 分素標的薬 / 癌 / 不死化 / がん / マイクロアレイ
Research Abstract

We have selected that TRA2B, a splicing factor, was a candidate gene participated in cancer-specific immortalization. TRA2B expression levels significantly differed among cancer cells and immortalized normal ones.
In this study, we revealed that cancer-related genes, such as MAD2L1 and tumor suppressor gene LATS2 have altered their expression levels in response to TRA2B knockdown. Furthermore, we found that TRA2B might regulate alternative splicing of 19 cancer-related genes. These results suggested that TRA2B was a possible upstream regulator of these genes, and may affect cancer cell growth via the regulation of these gene expressions and splicing pattern.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2013 2012

All Presentation (5 results) (of which Invited: 1 results)

  • [Presentation] TRA2Bによる癌細胞特異的バリアントの探索2013

    • Author(s)
      和田智
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2013-12-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 新規創薬標的TRA2Bの機能の解明2012

    • Author(s)
      和田智
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Search for variants of cancer related gene in alternative splicing caused by TRA2B2012

    • Author(s)
      和田智
    • Organizer
      日本癌学会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 新規創薬標的TRA2Bの機能の解明2012

    • Author(s)
      和田智
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] がん創薬標的TRA2Bの機能解析2012

    • Author(s)
      和田智
    • Organizer
      ロシュ454ユーザーセミナー
    • Place of Presentation
      ロシュ・ダイアグノスティックス本社
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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