| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Comprehensive methylation analysis of 20 gastric cancers revealed that the number of aberrantly methylated genes was highly variable between individual gastric NEC and adenocarcinoma. Among 715 genes of tumor-specific methylations discovered, 13 genes with promoter methylation in >30% of NECs and 0% of adenocarcinomas were identified. Some of these genes are known to regulate cell differentiation and cell cycle, and DNA methylation-silencing are suggested to be involved in carcinogenesis of gastric NECs.
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