Discover of genes associated with malignant potential of cancer cells
Project/Area Number |
24701004
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnosis
|
Research Institution | University of Toyama |
Principal Investigator |
ANDO Takayuki 富山大学, 大学院医学薬学研究部(医学), 助教 (30600671)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | DNAメチル化 / 突然変異 / 神経内分泌癌 / 腺癌 / DNAメチル化異常 / 胃神経内分泌癌 / 癌遺伝子 / 癌抑制遺伝子 / 胃癌 / 遺伝子変異 |
Outline of Final Research Achievements |
Comprehensive methylation analysis of 20 gastric cancers revealed that the number of aberrantly methylated genes was highly variable between individual gastric NEC and adenocarcinoma. Among 715 genes of tumor-specific methylations discovered, 13 genes with promoter methylation in >30% of NECs and 0% of adenocarcinomas were identified. Some of these genes are known to regulate cell differentiation and cell cycle, and DNA methylation-silencing are suggested to be involved in carcinogenesis of gastric NECs.
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Report
(4 results)
Research Products
(6 results)