| Project/Area Number |
24701019
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Akita University |
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Principal Investigator |
KOIZUMI Yukio 秋田大学, 医学(系)研究科(研究院), 助教 (80353465)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 放射線療法 / がん / G2期チェックポイント / 個別化療法 / 個別化治療 |
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| Outline of Final Research Achievements |
The aim of this study is to fuse two concepts of radiation sensitive marker, regenerating gene 1 (REG1), and G2 checkpoint inhibitor, to demonstrate the availability of combination therapy using radiotherapy and G2 checkpoint inhibitor, and to evaluate the feasibility of new personalized medicine focusing on radiotherapy. In this study, we proceeded to evaluate the relationship between expression of REG1 gene and X-ray sensitivity in esophageal cancer cell lines, and classified into four groups: 1) high expression of REG1 gene/X-ray sensitive, 2) high expression of REG1 gene/X-ray insensitive, 3) low expression of REG1 gene/X-ray sensitive, and 4) low expression of REG1 gene/X-ray insensitive sensitive.
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