Development of new hepatocellular carcinoma treatment method using a fatty acid synthesis inhibitor

• Project/Area Number: 24701020
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical oncology
• Research Institution: University of Tsukuba
• Principal Investigator: HASHIMOTO SHINJI 筑波大学, 医学医療系, 講師 (60624666)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝癌 / 脂肪酸合成酵素阻害剤 / 肝細胞癌

Research Abstract

Fatty acid synthase is highly expressed in many kinds of human cancers. Cerulenin, a natural inhibitor of fatty acid synthase, induced apoptosis in human hetatic cancer cell line Huh7, Hep3B and HepG2. Next, we made orthotopic xenograft model of human liver cancer Huh7, Hep3B and HepG2.Treatment effect is now under review.Based on these studies, inhibiting fatty acid synthase would be an effective strategy to treat unresectable hepatic cancer tumor.